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Tyrphostin AG1295

Tyrphostin AG1295

Product ID T9970
Cas No. 71897-07-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $96.00 In stock
5 mg $248.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tyrphostin AG1295 is an inhibitor of PDGFR that exhibits anti-fibrotic activity. Tyrphostin AG1295 prevents fibroblast cell growth, suppressing proliferative vitreoretinopathy in vivo. This compound also inhibits smooth muscle cell growth, migration, and activation, preventing neointimal formation after vascular balloon injury in other animal models.

Product Info

Cas No.

71897-07-9

Purity

≥98%

Formula

C16H14N2

Formula Wt.

234.30

Chemical Name

6,7-Dimethyl-2-phenylquinoxaline

IUPAC Name

6-(1-hydroxyethyl)-3-naphthalen-2-yl-7-oxo-1-azabicyclo[3.2.0]hept-2- ene-2-carboxylic acid

Melting Point

129-130°C

Solubility

Soluble in DMSO.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T9970 MSDS PDF

Info Sheet

T9970 Info Sheet PDF

References

Zheng Y, Ikuno Y, Ohj M, et al. Platelet-derived growth factor receptor kinase inhibitor AG1295 and inhibition of experimental proliferative vitreoretinopathy. Jpn J Ophthalmol. 2003 Mar-Apr;47(2):158-65. PMID: 12738549.

Banai S, Wolf Y, Golomb G, et al. PDGF-receptor tyrosine kinase blocker AG1295 selectively attenuates smooth muscle cell growth in vitro and reduces neointimal formation after balloon angioplasty in swine. Circulation. 1998 May 19;97(19):1960-9. PMID: 9609090.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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