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Tyrphostin AG1295 is an inhibitor of PDGFR that exhibits anti-fibrotic activity. Tyrphostin AG1295 prevents fibroblast cell growth, suppressing proliferative vitreoretinopathy in vivo. This compound also inhibits smooth muscle cell growth, migration, and activation, preventing neointimal formation after vascular balloon injury in other animal models.
| Cas No. | 71897-07-9 |
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| Purity | ≥98% |
| Formula | C16H14N2 |
| Formula Wt. | 234.30 |
| Chemical Name | 6,7-Dimethyl-2-phenylquinoxaline |
| IUPAC Name | 6-(1-hydroxyethyl)-3-naphthalen-2-yl-7-oxo-1-azabicyclo[3.2.0]hept-2- ene-2-carboxylic acid |
| Melting Point | 129-130°C |
| Solubility | Soluble in DMSO. |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Zheng Y, Ikuno Y, Ohj M, et al. Platelet-derived growth factor receptor kinase inhibitor AG1295 and inhibition of experimental proliferative vitreoretinopathy. Jpn J Ophthalmol. 2003 Mar-Apr;47(2):158-65. PMID: 12738549.
Banai S, Wolf Y, Golomb G, et al. PDGF-receptor tyrosine kinase blocker AG1295 selectively attenuates smooth muscle cell growth in vitro and reduces neointimal formation after balloon angioplasty in swine. Circulation. 1998 May 19;97(19):1960-9. PMID: 9609090.