• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Valproic Acid

Valproic Acid

Product ID V0148
Cas No. 99-66-1
Purity ≥98%
Product Unit SizeCostQuantityStock
10 g $47.80 In stock
25 g $102.30 In stock
100 g $204.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Valproic acid acts as an antagonist at T-type voltage-gated Ca2+ channels and voltage-gated Na+ channels; it also inhibits GABA transaminase, potentiating GABA signaling. Valproic acid is used clinically as an antiepileptic/anticonvulsant, although it also exhibits anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities. Valproic acid may also display antihypertensive benefit. In lung tissue, this compound prevents LPS-induced increases in TNF-α, IL-1β, NF-κB, NO, and iNOS. Valproic acid is an inhibitor of class I histone deacetylases (HDACs), primarily active against HDAC1, and downregulates expression of HDAC, VEGF, VEGFR2, and FGF, inhibiting tumor growth and angiogenesis in animal models.

Product Info

Cas No.

99-66-1

Purity

≥98%

Formula

C8H16O2

Formula Wt.

144.21

Chemical Name

2-propylpentanoic acid

IUPAC Name

2-propylpentanoic acid

Synonym

2-Propylpentanoic Acid; Dipropylacetic acid; Depakene; Depakine

Melting Point

120-130°C

Solubility

Water Solubility: 1.3mg/mL Freely soluble in 1N sodium hydroxide, methanol, alcohol, acetone, chloroform, benzene, ether, n-heptane; slightly soluble in 0.1 N hydrochloric acid

Appearance

Colorless liquid

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

V0148 MSDS PDF

Info Sheet

V0148 Info Sheet PDF

References

Zhang ZH, Hao CL, Liu P, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2014 Feb;9(2):443-9. PMID: 24297248.

Ji MH, Li GM, Jia M, et al. Valproic acid attenuates lipopolysaccharide-induced acute lung injury in mice. Inflammation. 2013 Dec;36(6):1453-9. PMID: 23846716.

Zhao L, Chen CN, Hajji N, et al. Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. Circulation. 2012 Jul 24;126(4):455-67. PMID: 22711276.

Rosenberg G. The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees? Cell Mol Life Sci. 2007 Aug;64(16):2090-103. PMID: 17514356.

Kelly KM, Gross RA, Macdonald RL. Valproic acid selectively reduces the low-threshold (T) calcium current in rat nodose neurons. Neurosci Lett. 1990 Aug 14;116(1-2):233-8. PMID: 2175404.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A2401

    AG-18

    EGFR and PDGFR inhibitor

    ≥98%
  • A5035

    5-Aminosalicylic Acid

    Salicylic acid derivative; PPARγ agonist, pote...

    ≥98%
  • A5327

    Anagrelide

    Imidazoquinazoline; PDE3 inhibitor.

    ≥98%
  • S680000

    SR144528

    Selective cannabinoid receptor 2 (CB2) inverse ...

    ≥98%
  • C002041

    Cabazitaxel

    Taxoid that disrupts the microtubular network i...

    ≥98%
  • D3322

    Diflunisal

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • E7377

    Estriol

    Endogenous steroid hormone, estradiol metabolit...

    ≥97%
  • F3205

    Fibrinogen γ-chain Dodecapeptide

    Platelet substitute, peptide; GP IIb/IIIa activ...

    ≥95%
  • L1616

    LEE-011

    CDK4/6 inhibitor.

    ≥98%
  • N5770

    Norfloxacin Hydrochloride

    First generation fluoroquinolone antibiotic.

    ≥98%
  • N1822

    Nefazodone Hydrochloride

    5-HT2 antagonist, SERT and NET inhibitor, hERG ...

    ≥98%
  • R176485

    Remdesivir

    SARS-CoV-2 inhibitor

    ≥99%
  • A016495

    5-Aminopyrimidine

    Building block

    ≥98%
  • F0048

    Famciclovir

    Penciclovir prodrug, nucleoside (guanosine) ana...

    ≥98%
  • E6994

    Erythromycin

    Macrolide; protein translation inhibitor, mamma...

    ≥94%
  • T5869

    Torcetrapib

    Cholesterol ester transfer protein inhibitor.

    ≥98%
  • D1643

    Delta Sleep Inducing Peptide

    Peptide; GABA potentiator, NMDA negative allost...

    ≥95%
  • L0284

    Lavendustin A

    Tyrosine kinase inhibitor.

    ≥97%
  • I5752

    Ionomycin, Free Acid

    Polyether Ca2+ ionophore.

    ≥98%, TLC, HPLC
  • T7044

    Triamcinolone Acetonide Acetate

    Steroid; glucocorticoid agonist.

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only