• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Valproic Acid

Valproic Acid

Product ID V0148
Cas No. 99-66-1
Purity ≥98%
Product Unit SizeCostQuantityStock
10 g $47.80 In stock
25 g $102.30 In stock
100 g $204.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Valproic acid acts as an antagonist at T-type voltage-gated Ca2+ channels and voltage-gated Na+ channels; it also inhibits GABA transaminase, potentiating GABA signaling. Valproic acid is used clinically as an antiepileptic/anticonvulsant, although it also exhibits anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities. Valproic acid may also display antihypertensive benefit. In lung tissue, this compound prevents LPS-induced increases in TNF-α, IL-1β, NF-κB, NO, and iNOS. Valproic acid is an inhibitor of class I histone deacetylases (HDACs), primarily active against HDAC1, and downregulates expression of HDAC, VEGF, VEGFR2, and FGF, inhibiting tumor growth and angiogenesis in animal models.

Product Info

Cas No.

99-66-1

Purity

≥98%

Formula

C8H16O2

Formula Wt.

144.21

Chemical Name

2-propylpentanoic acid

IUPAC Name

2-propylpentanoic acid

Synonym

2-Propylpentanoic Acid; Dipropylacetic acid; Depakene; Depakine

Melting Point

120-130°C

Solubility

Water Solubility: 1.3mg/mL Freely soluble in 1N sodium hydroxide, methanol, alcohol, acetone, chloroform, benzene, ether, n-heptane; slightly soluble in 0.1 N hydrochloric acid

Appearance

Colorless liquid

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

V0148 MSDS PDF

Info Sheet

V0148 Info Sheet PDF

References

Zhang ZH, Hao CL, Liu P, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2014 Feb;9(2):443-9. PMID: 24297248.

Ji MH, Li GM, Jia M, et al. Valproic acid attenuates lipopolysaccharide-induced acute lung injury in mice. Inflammation. 2013 Dec;36(6):1453-9. PMID: 23846716.

Zhao L, Chen CN, Hajji N, et al. Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. Circulation. 2012 Jul 24;126(4):455-67. PMID: 22711276.

Rosenberg G. The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees? Cell Mol Life Sci. 2007 Aug;64(16):2090-103. PMID: 17514356.

Kelly KM, Gross RA, Macdonald RL. Valproic acid selectively reduces the low-threshold (T) calcium current in rat nodose neurons. Neurosci Lett. 1990 Aug 14;116(1-2):233-8. PMID: 2175404.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • I0902

    Icaritin

    Flavonoid found in Epimedium.

    ≥98%
  • S1845

    L-(+)-Selenomethionine

    Naturally occurring amino acid found in grains,...

    ≥98%
  • A5272

    Angiotensin, dog/rat

    Peptide, derivative of AT I, cleavage product o...

    ≥95%
  • L5658

    Lonidamine

    Hexokinase inhibitor, aerobic glycolysis inhibi...

    ≥98%
  • B4517

    Bleomycin A5 Hydrochloride

    Glycopeptide, induces DNA strand breaks.  
    ≥90%
  • A046189

    Abexinostat

    Primarily targets HDAC1

    ≥98%
  • T9974

    [Asp371]-Tyrosinase (369-377), human

    Proteasome antigen.

    ≥95%
  • L0362

    Lapatinib free base

    Inhibitor of EGFR/HER2 (ErbB2).

    ≥99%
  • D0010

    3H-1,2-Dithiole-3-thione

    Induces activation of Nrf2; inhibits apoptosis ...

    ≥98%
  • D0011

    Dacarbazine

    DNA alkylator.

    ≥98%
  • R3586

    Rivastigmine Tartrate

    AChE and BChE inhibitor.

    ≥99%
  • A4933

    Amifostine Trihydrate

    Thiol prodrug, antioxidant.

    ≥98%
  • C6982

    Crustacean Cardioactive Peptide

    Neuropeptide hormone found in arthropods.

    ≥95%
  • L0076

    Latrunculin A

    Thiazolidine macrolide found in the Red Sea spo...

  • X4402

    XL-147

    Dual inhibitor of PI3K and mTOR.

    ≥98%
  • I7556

    1-Isothiocyanato-7-(methylsulfonyl)-heptane

    ITC, erysolin analog.

    ≥98%
  • G0104

    Gabexate Mesylate

    Proteasome inhibitor.

    ≥99%
  • T8269

    (S)-ar-Turmerone

    Sesquiterpene found in Curcuma.

    ≥97%
  • J023736

    (±)-Jasmonic Acid

    Phytohormone

    ≥98% (sum of isomers)
  • V5725

    Voglibose

    α-glucosidase inhibitor, potential GLP-1 agoni...

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only