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Valproic Acid

Valproic Acid

Product ID V0148
Cas No. 99-66-1
Purity ≥98%
Product Unit SizeCostQuantityStock
10 g $47.80 In stock
25 g $102.30 In stock
100 g $204.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Valproic acid acts as an antagonist at T-type voltage-gated Ca2+ channels and voltage-gated Na+ channels; it also inhibits GABA transaminase, potentiating GABA signaling. Valproic acid is used clinically as an antiepileptic/anticonvulsant, although it also exhibits anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities. Valproic acid may also display antihypertensive benefit. In lung tissue, this compound prevents LPS-induced increases in TNF-α, IL-1β, NF-κB, NO, and iNOS. Valproic acid is an inhibitor of class I histone deacetylases (HDACs), primarily active against HDAC1, and downregulates expression of HDAC, VEGF, VEGFR2, and FGF, inhibiting tumor growth and angiogenesis in animal models.

Product Info

Cas No.

99-66-1

Purity

≥98%

Formula

C8H16O2

Formula Wt.

144.21

Chemical Name

2-propylpentanoic acid

IUPAC Name

2-propylpentanoic acid

Synonym

2-Propylpentanoic Acid; Dipropylacetic acid; Depakene; Depakine

Melting Point

120-130°C

Solubility

Water Solubility: 1.3mg/mL Freely soluble in 1N sodium hydroxide, methanol, alcohol, acetone, chloroform, benzene, ether, n-heptane; slightly soluble in 0.1 N hydrochloric acid

Appearance

Colorless liquid

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

V0148 MSDS PDF

Info Sheet

V0148 Info Sheet PDF

References

Zhang ZH, Hao CL, Liu P, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2014 Feb;9(2):443-9. PMID: 24297248.

Ji MH, Li GM, Jia M, et al. Valproic acid attenuates lipopolysaccharide-induced acute lung injury in mice. Inflammation. 2013 Dec;36(6):1453-9. PMID: 23846716.

Zhao L, Chen CN, Hajji N, et al. Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. Circulation. 2012 Jul 24;126(4):455-67. PMID: 22711276.

Rosenberg G. The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees? Cell Mol Life Sci. 2007 Aug;64(16):2090-103. PMID: 17514356.

Kelly KM, Gross RA, Macdonald RL. Valproic acid selectively reduces the low-threshold (T) calcium current in rat nodose neurons. Neurosci Lett. 1990 Aug 14;116(1-2):233-8. PMID: 2175404.

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