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Vardenafil Dihydrochloride

Vardenafil Dihydrochloride

Product ID V0269
Cas No. 224789-15-5
Purity ≥99%
Product Unit SizeCostQuantityStock
10 mg $92.00 In stock
25 mg $132.60 In stock
100 mg $357.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Vardenafil is a centrally-acting phosphodiesterase 5 (PDE5) inhibitor that is clinically used to treat erectile dysfunction. Vardenafil also exhibits antioxidative and antihypertensive activities and shows some potential for synergistic chemotherapeutic ability through its modulation of cGMP-NO signaling. This compound increases expression of NO and eNOS as well as activity of superoxide dismutase, decreasing oxidative stress, pulmonary vascular resistance, and right ventricular hypertrophy and increasing cardiac output in animal models of pulmonary arterial hypertension (PAH). Vardenafil decreases proteinuria and glomerular damage in animal models of diabetic nephropathy-induced cGMP pathway dysfunction. In cellular models, vardenafil decreases secretion of IL-8 and expression of oxidative LDLR (LOX-1), suggesting potential benefit in the treatment of benign prostatic hyperplasia/low urinary tract syndrome (BPH/LUTS).

Product Info

Cas No.

224789-15-5

Purity

≥99%

Formula

C23H32N6O4S • 2HCl

Formula Wt.

561.52

Chemical Name

2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl- 1H-imidazo[5,1-f][1,2,4]triazin-4-one;dihydrochloride

IUPAC Name

2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl- 1H-imidazo[5,1-f][1,2,4]triazin-4-one;dihydrochloride

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

V0269 MSDS PDF

Info Sheet

V0269 Info Sheet PDF

References

Vignozzi L, Gacci M, Cellai I, et al. PDE5 inhibitors blunt inflammation in human BPH: a potential mechanism of action for PDE5 inhibitors in LUTS. Prostate. 2013 Sep;73(13):1391-402. PMID: 23765639.

Fan YF, Zhang R, Jiang X, et al. The phosphodiesterase-5 inhibitor vardenafil reduces oxidative stress while reversing pulmonary arterial hypertension. Cardiovasc Res. 2013 Aug 1;99(3):395-403. PMID: 23650288.

Fang L, Radovits T, Szabó G, et al. Selective phosphodiesterase-5 (PDE-5) inhibitor vardenafil ameliorates renal damage in type 1 diabetic rats by restoring cyclic 3',5' guanosine monophosphate (cGMP) level in podocytes. Nephrol Dial Transplant. 2013 Jul;28(7):1751-61. PMID: 23203993

Zhu B, Strada SJ. The novel functions of cGMP-specific phosphodiesterase 5 and its inhibitors in carcinoma cells and pulmonary/cardiovascular vessels. Curr Top Med Chem. 2007;7(4):437-54. PMID: 17305584.

Lau LC, Adaikan PG. Mechanisms of direct relaxant effect of sildenafil, tadalafil and vardenafil on corpus cavernosum. Eur J Pharmacol. 2006 Jul 17;541(3):184-90. PMID: 16777087.

Custom Order

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