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Vinblastine is a vinca alkaloid found in Catharanthus that exhibits immunosuppressive and anticancer chemotherapeutic activities. Vinblastine is an anti-mitotic that binds tubulin and inhibits proper microtubule polymerization, instead causing formation of curved or misshapen microtubules; it is clinically used to treat lymphomas, leukemias, breast cancer, and non-small cell lung cancer (NSCLC).
| Cas No. | 143-67-9 |
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| Purity | ≥96% |
| Formula | C46H58N4O9S • H2SO4 |
| Formula Wt. | 909.07 |
| Chemical Name | Vincaleukblastine sulfate |
| IUPAC Name | methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid |
| Synonym | Exal, Velban, Velbe |
| Melting Point | 267°C |
| Solubility | Slightly soluble in ethanol or water (10 parts). Practically insoluble in ether. |
| Appearance | White Crystal Powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Pliarchopoulou K, Laschos K, Pectasides D. Current chemotherapeutic options for the treatment of advanced bladder cancer: a review. Urol Oncol. 2013 Apr;31(3):294-302. PMID: 20843708.
Rendine S, Pieraccini S, Sironi M. Vinblastine perturbation of tubulin protofilament structure: a computational insight. Phys Chem Chem Phys. 2010 Dec 21;12(47):15530-6. PMID: 20978652.
Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer. 2004 Apr;4(4):253-65. PMID: 15057285.