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Vincristine Sulfate

Vincristine Sulfate

Product ID V5254
Cas No. 2068-78-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $71.50 In stock
10 mg $132.60 In stock
25 mg $195.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Vincristine is a vinca alkaloid found in Catharanthus that exhibits immunosuppressive and anticancer chemotherapeutic activities. Vincristine is an anti-mitotic that binds tubulin and inhibits microtubule polymerization; it is clinically used to treat lymphomas and leukemias and is one component of the CHOP chemotherapy cocktail. In melanoma cells, vincristine increases activation of AMPK and inhibition of mTORC1 signaling.

Product Info

Cas No.

2068-78-2

Purity

≥98%

Formula

C46H56N4O10 • H2O4S

Formula Wt.

923.05

Chemical Name

22-Oxovincaleukoblastine sulfate

IUPAC Name

methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid

Synonym

Kyocristine, Oncovin, Vincrex

Melting Point

273-281°C

Solubility

Soluble in water (50 mg/mL), methanol (20 mg/mL), PBS (2 mg/mL). Slightly soluble in ethanol or chloroform.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

V5254 MSDS PDF

Info Sheet

V5254 Info Sheet PDF

References

Wang L, Xia ZJ, Huang HQ, et al. Cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) in the treatment of stage IE/IIE extranodal natural killer/T cell lymphoma, nasal type: 13-year follow-up in 135 patients. Int J Hematol. 2012 Nov;96(5):617-23. PMID: 22983648.

Chen MB, Shen WX, Yang Y, et al. Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell. J Cell Physiol. 2011 Jul;226(7):1915-25. PMID: 21506122.

Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer. 2004 Apr;4(4):253-65. PMID: 15057285.

Custom Order

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