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Vitamin E, Natural

Vitamin E, Natural

Product ID V3276
Cas No. 59-02-9
Purity ≥97%
Product Unit SizeCostQuantityStock
10 g $54.60 In stock
100 g $123.80 In stock
250 g $257.80 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Vitamin E in its natural form is also known as D-α-tocopherol; it exhibits antioxidative, anti-inflammatory, anti-atherosclerotic, anti-hyperlipidemic, and anti-diabetic activities. In keratinocytes, vitamin E decreased UVA-induced upregulation of IL-8 and AP-1 binding and decreased activity of NADPH oxidase and formation of malondialdehyde. When administered clinically, vitamin E decreases ROS, lipid oxidation, secretion of IL-1β, and endothelial cell-to-monocyte adhesion. Vitamin E is also protective against retinal edema in animal models of ischemia/reperfusion. Additionally, vitamin E inhibits intracellular adhesion molecule 1 (ICAM-1)-induced activation of PKC in endothelial cells. In vivo, this compound decreases serum triglycerides, VLDL, PPARγ and malondialdehyde levels and increases PPARα levels, improving insulin resistance. Vitamin E also inhibits PKC-DAG signaling and increases glomerular filtration rate (GFR) and decreases albuminuria, showing nephroprotective benefit in animal models of diabetic nephropathy.

Product Info

Cas No.

59-02-9

Purity

≥97%

Formula

C29H50O2

Chemical Name

D-α-tocopherol

IUPAC Name

2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-ol

Melting Point

2-4°C

Appearance

Light yellow to brownish red viscous oil

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

V3276 MSDS PDF

Info Sheet

V3276 Info Sheet PDF

References

Kim do Y, Kim J, Ham HJ, et al. Effects of d-α-tocopherol supplements on lipid metabolism in a high-fat diet-fed animal model. Nutr Res Pract. 2013 Dec;7(6):481-7. PMID: 24353834.

Abdala-Valencia H, Berdnikovs S, Cook-Mills JM. Vitamin E isoforms differentially regulate intercellular adhesion molecule-1 activation of PKCα in human microvascular endothelial cells. PLoS One. 2012;7(7):e41054. PMID: 22815910.

Mirbagheri SA, Nezami BG, Assa S, et al. Rectal administration of d-alpha tocopherol for active ulcerative colitis: a preliminary report. World J Gastroenterol. 2008 Oct 21;14(39):5990-5. PMID: 18932276.

Wu S, Gao J, Dinh QT, et al. IL-8 production and AP-1 transactivation induced by UVA in human keratinocytes: roles of D-alpha-tocopherol. Mol Immunol. 2008 Apr;45(8):2288-96. PMID: 18206243.

Aydemir O, Celebi S, Yilmaz T, et al. Protective effects of vitamin E forms (alpha-tocopherol, gamma-tocopherol and d-alpha-tocopherol polyethylene glycol 1000 succinate) on retinal edema during ischemia-reperfusion injury in the guinea pig retina. Int Ophthalmol. 2004 Oct-Dec;25(5-6):283-9. PMID: 16532291.

Koya D, Haneda M, Kikkawa R, et al. d-alpha-tocopherol treatment prevents glomerular dysfunctions in diabetic rats through inhibition of protein kinase C-diacylglycerol pathway. Biofactors. 1998;7(1-2):69-76. PMID: 9523030.

Devaraj S, Li D, Jialal I. The effects of alpha tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1 beta secretion, and monocyte adhesion to endothelium. J Clin Invest. 1996 Aug 1;98(3):756-63. PMID: 8698868.

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