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WH-4-023

WH-4-023

Product ID W2800
Cas No. 837422-57-8
Purity ≥99 %
Product Unit SizeCostQuantityStock
1 mg $135.10 In stock
5 mg $253.20 In stock
25 mg $759.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

WH-4-023 inhibits Lck, Src, and SIK. In macrophage models, this compound exhibits immunomodulatory activity, inhibiting T cell activation and increasing IL-10 production.

Product Info

Cas No.

837422-57-8

Purity

≥99 %

Formula

C32H36N6O4

Formula Wt.

568.68

IUPAC Name

2,6-Dimethylphenyl (2,4-dimethoxyphenyl)(2-{[4-(4-methyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)carbamate

Synonym

KIN112

Solubility

DMSO 12 mg/mL Ethanol 6 mg/mL Water Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

W2800 MSDS PDF

Info Sheet

W2800 Info Sheet PDF

References

Clark K, MacKenzie KF, Petkevicius K, et al. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91. PMID: 23033494.

Martin MW, Newcomb J, Nunes JJ, et al. Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity. J Med Chem. 2006 Aug 10;49(16):4981-91. PMID: 16884310.

Custom Order

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