Description
WH-4-023 inhibits Lck, Src, and SIK. In macrophage models, this compound exhibits immunomodulatory activity, inhibiting T cell activation and increasing IL-10 production.
WH-4-023
Product ID W2800
Cas No. 837422-57-8
Purity ≥99 %
| Product Unit Size | Cost | Quantity | Stock |
|---|
Product Info
| Cas No. | 837422-57-8 |
|---|---|
| Purity | ≥99 % |
| Formula | C32H36N6O4 |
| Formula Wt. | 568.68 |
| IUPAC Name | 2,6-Dimethylphenyl (2,4-dimethoxyphenyl)(2-{[4-(4-methyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)carbamate |
| Synonym | KIN112 |
| Solubility | DMSO 12 mg/mL Ethanol 6 mg/mL Water Insoluble |
Shipping and Storage
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
Downloads
| MSDS | |
|---|---|
| Info Sheet |
References
Clark K, MacKenzie KF, Petkevicius K, et al. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91. PMID: 23033494.
Martin MW, Newcomb J, Nunes JJ, et al. Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity. J Med Chem. 2006 Aug 10;49(16):4981-91. PMID: 16884310.