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ZM-336372

ZM-336372

Product ID Z4833
Cas No. 208260-29-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $116.80 In stock
25 mg $476.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

ZM-336372 is a small molecule that acts as a tyrosine kinase inhibitor and Raf-1 activator. ZM-336372 exhibits anticancer chemotherapeutic activity, increasing apoptosis, suppressing tumor growth, upregulating expression of cell cycle inhibitors, and decreasing neuroendocrine vasoactive peptide production in a variety of cell types.

Product Info

Cas No.

208260-29-1

Purity

≥98%

Formula

C23H23N3O3

Formula Wt.

389.45

Chemical Name

Benzamide, 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-

IUPAC Name

3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl] benzamide

Solubility

DMSO 78 mg/mL (200.28 mM) Ethanol 2 mg/mL (5.13 mM) Water Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

Z4833 MSDS PDF

Info Sheet

Z4833 Info Sheet PDF

References

Deming D, Geiger P, Chen H, et al. ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines. J Surg Res. 2010 Jun 1;161(1):28-32. PMID: 20031160.

Deming D, Geiger P, Chen H, et al. ZM336372, a Raf-1 activator, causes suppression of proliferation in a human hepatocellular carcinoma cell line. J Gastrointest Surg. 2008 May;12(5):852-7. PMID: 18299943.

Kappes A, Vaccaro A, Kunnimalaiyaan M, et al. ZM336372, a Raf-1 activator, inhibits growth of pheochromocytoma cells. J Surg Res. 2006 Jun 1;133(1):42-5. PMID: 16603190.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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