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Zoledronate Disodium Tetrahydrate

Zoledronate Disodium Tetrahydrate

Product ID Z5645
Cas No. 165800-07-7
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $78.10 In stock
10 mg $128.60 In stock
25 mg $236.40 In stock
100 mg $661.80 In stock
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  • Product Info
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  • Description
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Description

Zoledronate is a sodium salt form of zoledronic acid. Zoledronic acid is a third generation bisphosphonate that exhibits anti-resorptive, anti-osteoporotic, anti-angiogenic, and anticancer chemotherapeutic activities. In giant cell tumor bone stromal cells, zoledronic acid increases expression of Cbfa-1, osteocalcin, and osterix, inducing apoptosis and osteogenic differentiation; it also inhibits bone resorption and prevents osteoporosis in animal models. In animal models of renal cell carcinoma, zoledronic acid decreases mean vessel density. In breast cancer cells, zoledronic acid reverses the epithelial-to-mesenchymal transition (EMT) by inactivating NF-κB, decreasing self-renewal and cell proliferation. In other cellular models, zoledronic acid inhibits farnesyl diphosphate synthase (FPPS), which results in activation of γδ T cells. Across several breast cancer cell lines, zoledronic acid activates caspases 3, 8, and 9 and decreases expression of Ras and MAPK, resulting in the induction of cell cycle arrest or apoptosis.

Product Info

Cas No.

165800-07-7

Purity

≥98%

Formula

C5H10N2O7P2 • 2Na • 4H2O

Formula Wt.

390.13

Chemical Name

[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]- bisphosphonic acid disodium salt tetrahydrate

IUPAC Name

disodium;(1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid;tetrahydrate

Synonym

Zoledronic acid disodium salt tetrahydrate

Melting Point

305-307°C

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

Z5645 MSDS PDF

Info Sheet

Z5645 Info Sheet PDF

References

Yang T, Zheng XF, Li M, et al. Stimulation of osteogenic differentiation in stromal cells of giant cell tumour of bone by zoledronic acid. Asian Pac J Cancer Prev. 2013;14(9):5379-83. PMID: 24175830.

Schech AJ, Kazi AA, Gilani RA, et al. Zoledronic acid reverses the epithelial-mesenchymal transition and inhibits self-renewal of breast cancer cells through inactivation of NF-κB. Mol Cancer Ther. 2013 Jul;12(7):1356-66. PMID: 23619300.

Idrees AS, Sugie T, Inoue C, et al. Comparison of γδ T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid. Cancer Sci. 2013 May;104(5):536-42. PMID: 23387443.

Ibrahim T, Mercatali L, Sacanna E, et al. Inhibition of breast cancer cell proliferation in repeated and non-repeated treatment with zoledronic acid. Cancer Cell Int. 2012 Nov 22;12(1):48. PMID: 23173568.

Soltau J, Zirrgiebel U, Esser N, et al. Antitumoral and antiangiogenic efficacy of bisphosphonates in vitro and in a murine RENCA model. Anticancer Res. 2008 Mar-Apr;28(2A):933-41. PMID: 18507039.

Kavanagh KL, Guo K, Dunford JE, et al The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7829-34. PMID: 16684881.

Takahashi H, Kinbara M, Sato N, et al. Nickel allergy-promoting effects of microbial or inflammatory substances at the sensitization step in mice. Int Immunopharmacol. 2011 Oct;11(10):1534-1540. PMID: 21621645.

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