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Phenylbutazone is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-1 and COX-2 activity; it is no longer used in humans, but was previously used to treat inflammatory diseases such as arthritis and gout. Phenylbutazone exhibits anti-inflammatory, analgesic, antipyretic, and antioxidative activities. In vivo, phenylbutazone decreases edema; in separate cellular models, it inhibits activity of myeloperoxidase.
| Cas No. | 50-33-9 |
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| Purity | ≥98% |
| Formula | C19H20N2O2 |
| Formula Wt. | 308.37 |
| Chemical Name | 4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione |
| IUPAC Name | 4-butyl-1,2-diphenylpyrazolidine-3,5-dione |
| Synonym | Ambene, Artrizin, Butadion, Butoz, Equipalazone, Fenibutol, Intrabutazone, Phenyzene, Tevcodyne, Uzone |
| Melting Point | 105°C |
| Solubility | Soluble in water. |
| Appearance | White to off white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Cusan C, Altinier G, Sosa S, et al. Anti-inflammatory and anti-oxidant activity of a new class of phenyl-pyrazolone derivatives. Curr Drug Discov Technol. 2006 Mar;3(1):67-73. PMID: 16712464.
Kettle AJ, Winterbourn CC. Mechanism of inhibition of myeloperoxidase by anti-inflammatory drugs. Biochem Pharmacol. 1991 May 15;41(10):1485-92. PMID: 1850278.