Prednisolone Sodium Phosphate

Name: Prednisolone Sodium Phosphate
SKU: P7012
Availability: InStock

Product ID P7012

Cas No. 125-02-0

Purity ≥98%

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Description

Prednisolone is a derivative of cortisol and a metabolite of prednisone; it exhibits immunosuppressive and anti-inflammatory activities. Prednisolone activates glucocorticoid receptors and is clinically used to treat inflammatory and autoimmune disorders. In mononuclear cells from subjects with multiple sclerosis, prednisolone decreases expression of T-bet, IFNγ, and phosphorylated STAT1, decreasing lymphocyte apoptosis. Additionally, prednisolone delays the progression of Duchenne muscular dystrophy (DMD), altering muscle fiber types in vivo. This form of prednisolone is water soluble.

Product Info

Cas No.	125-02-0
Purity	≥98%
Formula	C₂₁H₂₇Na₂O₈P
Formula Wt.	484.39
Chemical Name	11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-(disodium phosphate)
IUPAC Name	disodium;[2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15, 16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl] phosphate
Synonym	Hydeltrasol, Prednisolone 21-phosphate disodium
Solubility	Soluble in water (250 mg/ mL), methanol (77 mg/mL) and ethanol.
Appearance	White to off white powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	P7012 MSDS PDF
Info Sheet	P7012 Info Sheet PDF

References

Frisullo G, Nociti V, Iorio R, et al. Glucocorticoid treatment reduces T-bet and pSTAT1 expression in mononuclear cells from relapsing remitting multiple sclerosis patients. Clin Immunol. 2007 Sep;124(3):284-93. PMID: 17627892.

Fisher I, Abraham D, Bouri K, et al. Prednisolone-induced changes in dystrophic skeletal muscle. FASEB J. 2005 May;19(7):834-6. Erratum in: FASEB J. 2005 May;19(7):1 p following 836. Hoffmann, Eric P [corrected to Hoffman, Eric P]. PMID: 15734791.

Davis M, Williams R, Chakraborty J, et al. Prednisone or prednisolone for the treatment of chronic active hepatitis? A comparison of plasma availability. Br J Clin Pharmacol. 1978 Jun;5(6):501-5. PMID: 656293.

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Prednisolone Sodium Phosphate

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Description

Product Info

Shipping and Storage

Downloads

References

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