Incensol Acetate

Name: Incensol Acetate
SKU: I524088
Availability: InStock

Product ID I524088

Cas No. 34701-53-6

Purity ≥98%

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Description

Incensol acetate is a natural constituent found in frankincense resin and is a potent bioactive diterpenic cembrenoid. Frankincense extract has traditionally been used to treat various inflammatory diseases including arthritis. Several of the individual components in frankincense, including incensol acetate, have shown anti-inflammatory activity in mice. Incensol acetate was found to activate transient receptor potential vanilloid 3, a protein that is involved in temperature sensation in the skin, hair growth, and neurological activities. Incensol acetate has also been found to inhibit activation of Burkitt’s lymphoma derived Raji cells, and in addition, has shown an antidepressant-like effect in the forced swim test in mice, and possibly modulates the hypothalamic-pituitary-adrenal axis.

Product Info

Cas No.	34701-53-6
Purity	≥98%
Formula	C₂₂H₃₆O₃
Formula Wt.	348.53
Chemical Name	(1R,2S,5E,9E,12S)-(9Cl)-1,5,9-Trimethyl-12-(1-methylethyl)-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-ol acetate
IUPAC Name	(1,5,9-trimethyl-12-propan-2-yl-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-yl) acetate
Synonym	Incensole Acetate, (+)-Incensol acetate, (+)-Incensole acetate
Solubility	Soluble in DMSO, dichloromethane or ethyl ether. Insoluble in water. Almost insoluble in ethanol or methanol.

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	I524088 MSDS PDF
Info Sheet	I524088 Info Sheet PDF

References

Banno N, Akihisa T, Yasukawa K, et al. Anti-inflammatory activities of the triterpene acids from the resin of Boswellia carteri. J Ethnopharmacol. 2006 Sep 19;107(2):249-253. PMID: 16621377.

Pollastro F, Golin S, Chianese G, et al. Neuroactive and anti-inflammatory frankincense cembranes: a structure-activity study. J Nat Prod. 2016 Jul 22;79(7):1762-1768. PMID: 27352042.

Akihisa T, Tabata K, Banno N, et al. Cancer chemopreventive effects and cytotoxic activities of the triterpene acids from the resin of Boswellia carteri. Biol Pharm Bull. 2006 Sep;29(9):1976-1979. PMID: 16945622.

Moussaieff A, Gross M, Nesher E, et al. Incensole acetate reduces depressive-like behavior and modulates hippocampal BDNF and CRF expression in submissive animals. J Psychopharmacol. 2012 Dec;26(12);1584-1593. PMID: 23015543.

Moussaieff A, Yu J, Zhu H, et al. Protective effects of incensole acetate on cerebral ischemic injury. Brain res. 2012 Mar 14;1443:89-97. PMID: 22284622.

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Incensol Acetate

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