LKT Labs

Biochemicals for Life Science Research

A 83-01

A 83-01

Product ID A001001
Cas No. 909910-43-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $78.80 In stock
25 mg $257.30 In stock
100 mg $787.50 In stock
Bulk Quote

Quicklinks

Description

A 83-01 is a TGFbeta receptor inhibitor found to suppress over-expression of pro-fibrogenic factors. When applied in concert with Y27632 and CHIR99021, A 83-01 treatment resulted in transformation of rat mature hepatocytes into proliferative bipotent cells. A study on a mouse model treated with A 83-01 resulted in decrease in cardiac fibrosis and increase in miocardial viability. Topical application of A 83-01 to second-degree burns in rat skin reduced wound contraction during healing without delaying the wound closure.

Product Info

Cas No.

909910-43-6
Purity

≥98%
Formula

C25H19N5S
Formula Wt.

421.52
Chemical Name

3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
IUPAC Name

3-(6-methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide
Synonym

A83-01; ALK5 Inhibitor IV; 1H-Pyrazole-1-carbothioamide,3-(6-methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-
Solubility

Soluble in DMSO 1mg/mL in ethanol 2.5mg/mL in ethyl acetate
Appearance

White to off-white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A001001 MSDS PDF
Info Sheet

A001001 Info Sheet PDF

References

Katsuda T, Kawamata M, Hagiwara K, et al. Conversion of terminally committed hepatocytes to culturable bipotent progenitor cells with regenerative capacity. Cell Stem Cell. 2017 Jan 5;20(1):41-55. PMID: 27840021.

Wang H, Liu S, Wang Y, et al. Nod-like receptor protein 3 inflammasome activation by Escherichia coli RNA induces transforming growth factor beta 1 secretion in hepatic stellate cells. Bosn J Basic Med Sci. 2016 Jan 14;16(2):126-131. PMID: 26773180.

Nishino Y, Murakami M, Funaba M. Expression and role of the TGF-beta family in glial cells infected with Borna disease virus. Microbes Infect. 2016 Feb;18(2):128-136. PMID: 26482505.

Ho YS, Tsai WH, Lin FC, et al. Cardioprotective actions of TGFbetaRI inhibition through stimulating autocrine/paracrine of survivin and inhibiting Wnt in cardiac progenitors. Stem Cells. 2016 Feb;34(2):445-455. PMID: 26418219.

Sun X, Kim YH, Phan TN, et al. Topical application of ALK5 inhibitor A-83-01 reduces burn wound contraction in rats by suppressing myofibroblast population. Biosci Biotechnol Biochem. 2014;78(11):1805-1812. PMID: 25351330.

Nishino Y

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • F1895

    Fexofenadine Hydrochloride

    Histamine H1 antagonist.

    ≥98%
  • C6132

    CPI-203

    Triazolothienodiazepine, JQ-1 derivative; BRD i...

    ≥98%
  • I088240

    (S,S)-ICG-001

    Wnt/β-catenin inhibitor

    ≥98%
  • L1616

    LEE-011

    CDK4/6 inhibitor.

    ≥98%
  • F4680

    Flutamide

    Non-steroid; AR antagonist.

    ≥98%
  • C5662

    Copper Bis-3,5-diisopropylsalicylate

    Antioxidant.

    ≥97%
  • C9809

    Cyclopiazonic Acid

    SERCA inhibitor.

    ≥98%, TLC
  • K0088

    Kawain

    Kavalactone originally found in Piper methystic...

    ≥98%
  • G124090

    GDC-6036

    KRAS inhibitor

    ≥98%
  • P6858

    Procarbazine Hydrochloride

    Hydrazine derivative, DNA alkylator; MAO inhibi...

    ≥97%
  • C2956

    Cholecalciferol

    Endogenous vitamin D prodrug.

    ≥98%
  • C0020

    Cafestol

    Diterpene found in brewed, unfiltered coffee; F...

    ≥98%
  • A0933

    Acitretin

    Retinoid; RARα/β/γ agonist.

    ≥98%, multiple isomers
  • D1769

    Dermorphin

    Opioid peptide; μOR agonist.

    ≥96%
  • I1400

    Idarubicin Hydrochloride

    Anthracycline, DNA intercalator; topoisomerase ...

    ≥98%
  • L9600

    LY-2090314

    GSK-3 inhibitor.

    ≥98%
  • R3224

    Rigin

    Peptide, IgG derivative, tuftsin analog.

    ≥95%
  • C5863

    Coptisine Chloride, natural

    Isoquinoline alkaloid found in a variety of pla...

    ≥98%
  • D6108

    1,4-DPCA

    Prolyl hydroxylase inhibitor.

    ≥98%
  • A1607

    AEBSF Hydrochloride

    Serine protease substrate/inhibitor.

    ≥98%