LKT Labs

Biochemicals for Life Science Research

Carbamazepine

Carbamazepine

Product ID C0270
Cas No. 298-46-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $42.00 In stock
5 g $87.00 In stock
25 g $278.00 In stock
Bulk Quote

Quicklinks

Description

Carbamazepine is an antiepileptic/anticonvulsant that also exhibits antipsychotic and anti-inflammatory activities. Carbamazepine inhibits voltage-gated Na+ channels, stabilizing the inactive conformation of the channel. Carbamazepine also potentiates GABA receptor signaling and inhibits ATP-sensitive K+ channels. Carbamazepine is clinically used to treat epilepsy, bipolar disorder, neuralgia/neuropathic pain, ADHD, schizophrenia, and post-traumatic stress disorder (PTSD). In animal models, carbamazepine decreases LPS-induced expression of TNF-α and IL-1β.

Product Info

Cas No.

298-46-4
Purity

≥98%
Formula

C15H12N2O
Formula Wt.

236.27
Chemical Name

5H-Dibenz[b,f]azepine-5-carboxamide
IUPAC Name

benzo[b][1]benzazepine-11-carboxamide
Synonym

Biston, Carbatrol, Epitol, Sirtal, Telesmin, Timonil
Melting Point

190-193°C
Solubility

Soluble in alcohol, acetone or propylene glycol. Practically insoluble in water.

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

C0270 MSDS PDF
Info Sheet

C0270 Info Sheet PDF

References

Gómez CD, Buijs RM, Sitges M. The anti-seizure drugs vinpocetine and carbamazepine, but not valproic acid, reduce inflammatory IL-1β and TNF-α expression in rat hippocampus. J Neurochem. 2014 Jun 5. [Epub ahead of print]. PMID: 24903676.

Zhou Q, Chen PC, Devaraneni PK, et al. Carbamazepine inhibits ATP-sensitive potassium channel activity by disrupting channel response to MgADP. Channels (Austin). 2014 May 21;8(4). [Epub ahead of print]. PMID: 24849284.

Rahman W, Dickenson AH. Voltage gated sodium and calcium channel blockers for the treatment of chronic inflammatory pain. Neurosci Lett. 2013 Dec 17;557 Pt A:19-26. PMID: 23941888.

Bialer M. Why are antiepileptic drugs used for nonepileptic conditions? Epilepsia. 2012 Dec;53 Suppl 7:26-33. PMID: 23153207.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • W3576

    Withaferin A

    Steroid lactone produced by Withania somnifera;...

    ≥98%
  • P7034

    Prion Peptide (106-126), human

    Synthetic peptide fragment, prion protein analo...

    ≥95%
  • A1202

    Adapalene

    Tretinoin analog; RARα/β/γ agonist.

    ≥98%
  • E5576

    Entecavir

    Nucleoside (deoxyguanosine) analog; DNA chain t...

    ≥97%
  • S7061

    SRPIN340

    SRPK1 inhibitor.

    ≥98%
  • O4532

    Oligomycin B

    Macrolide; F1F0 ATP synthase inhibitor.

    ≥97%, TLC, HPLC
  • K0054

    Kanamycin B

    Aminoglycoside; protein translation inhibitor, ...

    ≥98%
  • L0108

    Lacidipine

    Calcium channel blocker.

    ≥98%
  • C294458

    Chlorzoxazone

    Centrally acting muscle relaxant.

    ≥99%
  • S584780

    Sotorasib racemate

    KRAS inhibitor

    ≥99%
  • O9257

    16-Oxokahweol

    Synthetic kahweol derivative.

    ≥95%
  • B8176

    2-n-Butylthiophene

    Sulfur analog of furan found in cooked meat pro...

    ≥98%
  • L0107

    Lactacystin

    Found in Streptomyces; proteasome inhibitor.

    ≥98%
  • L0360

    Lapatinib Ditosylate Monohydrate

    EGFR inhibitor.

    ≥99%
  • T1750

    Temocapril Hydrochloride

    ACE inhibitor.

    ≥98%
  • C9710

    Cyclopamine

    Steroidal jerveratrum alkaloid found in Veratru...

    ≥98%
  • T0093

    2′-Acetyltaxol

    Taxane synthesis intermediate.

    ≥98%
  • P5747

    Polymyxin B sulfate

    Cationic lipid polypeptide, mixture of polymyxi...

    ≥6500 iu/mg
  • S760004

    Stachybotrylactam

    Spirodihydrobenzofuranlactam

    ≥98%
  • I7556

    1-Isothiocyanato-7-(methylsulfonyl)-heptane

    ITC, erysolin analog.

    ≥98%