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Cytisine is an alkaloid originally found in Laburnum, Cytisus, and other Fabaceae-family plants. Cytisine exhibits antidepressant activity in vivo and activates nicotinic acetylcholine receptors (nAChRs), acting as a partial agonist at α4β2 nAChRs and a full agonist at α3β4 nAChRs. Cytisine is structurally similar to nicotine and shows some clinical benefit in increasing smoking cessation rates.
| Cas No. | 485-35-8 |
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| Purity | ≥98% |
| Formula | C11H14N2O |
| Formula Wt. | 190.24 |
| IUPAC Name | (1R,9S)-7,11-diazatricyclo[7.3.1.02,7]trideca-2,4-dien-6-one |
| Synonym | (-)-Cytisine |
| Melting Point | 154-156°C |
| Appearance | White Crystal Powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Hajek P, McRobbie H, Myers K. Efficacy of cytisine in helping smokers quit: systematic review and meta-analysis. Thorax. 2013 Nov;68(11):1037-42. PMID: 23404838.
Simeonova R, Vitcheva V, Mitcheva M. Effect of cytisine on some brain and hepatic biochemical parameters in spontaneously hypertensive rats. Interdiscip Toxicol. 2010 Mar;3(1):21-5. PMID: 21217867.
Mineur YS, Somenzi O, Picciotto MR. Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice. Neuropharmacology. 2007 Apr;52(5):1256-62. PMID: 17320916.