Description
AZ-5104 is an active metabolite of AZD-9291 (osimertinib), an inhibitor of EGFR. It has shown efficacy in models of non-small cell lung cancer.
Product Unit Size | Cost | Quantity | Stock |
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AZ-5104 is an active metabolite of AZD-9291 (osimertinib), an inhibitor of EGFR. It has shown efficacy in models of non-small cell lung cancer.
Cas No. | 1421373-98-9 |
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Purity | ≥98% |
Formula | C27H31N7O2 |
Formula Wt. | 485.59 |
IUPAC Name | N-(2-{[2-(Dimethylamino)ethyl](methyl)amino}-5-{[4-(1H-indol-3-yl)-2-pyrimidinyl]amino}-4-methoxyphenyl)acrylamide |
Synonym | AZ-5104, AZ 5104, AZ5104 |
Store Temp | -20°C |
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Ship Temp | Ambient |
MSDS | |
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Info Sheet |
Yates J. Ashton S., et al. Irreversible Inhibition of EGFR: Modeling the Combined Pharmacokinetic-Pharmacodynamic Relationship of Osimertinib and Its Active Metabolite AZ5104. Mol Cancer Ther. 15(10):2378-87 (2016). PMID: 27439477.
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