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GSK-2982772 is an inhibitor of receptor interacting protein 1 (RIP1), a regulator of necroptosis and inflammation. It has the potential to treat a variety of chronic inflammatory diseases such as psoriasis, rheumatoid arthritis, and ulcerative colitis.
| Cas No. | 1622848-92-3 |
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| Purity | ≥98% |
| Formula | C20H19N5O3 |
| Formula Wt. | 377.40 |
| IUPAC Name | 3-Benzyl-N-[(3S)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-1H-1,2,4-triazole-5-carboxamide |
| Synonym | GSK 2982772, GSK2982772 |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Harris P., Berge S., et al. Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases. J Med Chem. 60(4):1247-61 (2017). PMID: 28151659.