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Spiramycin is a macrolide antibiotic that is clinically used to treat toxoplasmosis and other soft tissue infections. Spiramycin exhibits antibacterial efficacy against Toxoplasma, inhibiting bacterial protein synthesis. In vitro, spiramycin decreases levels of IL-10 and TNF-α, and in vivo, it decreases Toxoplasma-induced brain cysts.
| Cas No. | 67724-08-7 |
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| Purity | Spiramycin 67-73%, embonic acid 27-33% |
| IUPAC Name | 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2- carboxylic acid;2-[(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-[(2S,3R,4R,5S,6R)-5-[(2S,4R, 5S,6S)-4,5-dihydroxy-4, 6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl] oxy-10-[(2S,5S, 6R)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-4-hydroxy-5-methoxy-9, 16-dimethyl-2-oxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde |
| Synonym | Spira 200 |
| Solubility | Soluble in most organic solvents |
| Appearance | Slightly yellowish powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Kieffer F, Wallon M. Congenital toxoplasmosis. Handb Clin Neurol. 2013;112:1099-101. PMID: 23622316.
Büyükbaba Boral O, Sönmez Tamer G, Keçeli Özcan S, et al. Investigation of combined effectiveness of spiramycin and beta-glucan in mice models of acute toxoplasmosis and determination of IL-10, IL-12 and TNF-α levels. Mikrobiyol Bul. 2012 Jul;46(3):446-55. PMID: 22951656.
Chew WK, Segarra I, Ambu S, et al. Significant reduction of brain cysts caused by Toxoplasma gondii after treatment with spiramycin coadministered with metronidazole in a mouse model of chronic toxoplasmosis. Antimicrob Agents Chemother. 2012 Apr;56(4):1762-8. PMID: 22271863.