LKT Labs

Biochemicals for Life Science Research

Nocistatin

Nocistatin

Product ID N5211
Cas No.
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $204.40 Please Inquire
10 mg $262.50 Please Inquire
Bulk Quote

Quicklinks

Description

Nocistatin is a neuromodulatory peptide that exhibits antinociceptive, neuroprotective, and anxiogenic activities. Ca2+-sensitive (BK, IK, SK) K+ channels mediate the inhibitory action of nocistatin on muscle contractions in the uterus. Nocistatin activates transient receptor potential canonical (TRPC) channels via GPCR/PLC/PKC signaling pathways and inhibits thermal hyperalgesia induced by nociceptin. Nocistatin also inhibits memory acquisition impairment induced by nociceptin. Additionally, this peptide inhibits release of 5-HT in synaptosomes and induces anxiogenic activity in animal models undergoing elevated plus maze testing.

Product Info

Purity

≥95%
Formula

C32H56N10O12
Formula Wt.

772.86

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

N5211 MSDS PDF
Info Sheet

N5211 Info Sheet PDF
Brochures

TRP Channel Modulator Flyer

References

Deák BH, Klukovits A, Tekes K, et al. Nocistatin inhibits pregnant rat uterine contractions in vitro: roles of calcitonin gene-related peptide and calcium-dependent potassium channel. Eur J Pharmacol. 2013 Aug 15;714(1-3):96-104. PMID: 23792038.

Chen YL, Li AH, Yeh TH, et al. Nocistatin and nociceptin exert opposite effects on the excitability of central amygdala nucleus-periaqueductal gray projection neurons. Mol Cell Neurosci. 2009 Jan;40(1):76-88. PMID: 18930828.

Fantin M, Fischetti C, Trapella C, et al. Nocistatin inhibits 5-hydroxytryptamine release in the mouse neocortex via presynaptic Gi/o protein linked pathways. Br J Pharmacol. 2007 Oct;152(4):549-55. PMID: 17618307.

Liu EH, Lee TL, Nishiuchi Y, et al. Nocistatin and its derivatives antagonize the impairment of short-term acquisition induced by nociceptin. Neurosci Lett. 2007 Apr 12;416(2):155-9. PMID: 17306455.

Liu EH, Nishiuchi Y, Kimura T, et al. Supraspinal nocistatin and its amide derivative antagonize the hyperalgesic effects of nociceptin in mice. Neurosci Lett. 2006 Apr 10-17;397(1-2):59-63. PMID: 16384642.

Gavioli EC, Rae GA, Calo' G, et al. Central injections of nocistatin or its C-terminal hexapeptide exert anxiogenic-like effect on behaviour of mice in the plus-maze test. Br J Pharmacol. 2002 Jul;136(5):764-72. PMID: 12086986.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • R0161

    Rapamycin

    Macrolide originally produced by Streptomyces; ...

    ≥99%
  • M568268

    Mogroside IV

    Triterpenoid

    ≥98%
  • A5301

    Anacetrapib

    Cholesterol ester transfer protein inhibitor.

    ≥98%
  • C4657

    Clotrimazole

    Imidazole; 14-α demethylase, H+/K+ ATPase, Na+...

    ≥97%
  • H9612

    Hydrocortisone 21-Acetate

    Steroid hormone involved in stress signaling; g...

    ≥98%
  • C3576

    Citreoviridin A

    Mycotoxin; F1F0 ATP synthase inhibitor.

    ≥95%
  • T6811

    Tranexamic Acid

    Plasminogen inhibitor.

    ≥98%
  • A2048

    Aflatoxin G1

    Mycotoxin produced by species of Aspergillus; D...

    ≥98%
  • R3584

    Rivaroxaban

    Oxazolidone derivative; Factor Xa inhibitor.

    ≥98%
  • T5968

    Torsemide

    Loop diuretic; NKCC symporter and HSP90 inhibit...

    ≥99%
  • V9202

    VX-702

    p38 MAPK inhibitor.

    ≥98%
  • A480020

    (R,S)-AM 1241

    Cannabinoid receptor 2 selective agonist.

    ≥96%
  • K0030

    Kahweol

    Diterpene found in coffee beans.

    ≥97%
  • C9673

    Cysteamine Hydrochloride

    Aminothiol, CoA component; ulcer inducer.

    ≥99%
  • P6852

    Propafenone Hydrochloride

    β-adrenergic antagonist, Kv1.4 and K2P2 K+ cha...

    ≥98%
  • C0254

    Candesartan Celexetil Ester

    AT1 inhibitor.

    ≥98%
  • L8010

    D-Luciferin Potassium

    Heterocyclic light-emitting compound, natural l...

    ≥98%
  • T1777

    S,S-(+)-Tetrandrine

    Benzylisoquinoline alkaloid originally found in...

    ≥98%
  • P2012

    PF-04217903

    Triazolopyrazine; c-MET inhibitor.

    ≥98%
  • L3326

    Ligustrazine Hydrochloride

    Dihydropyrazine found in Ligusticum walliichi. ...

    ≥98%