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Disodium Cycloheptylaminomethylene Diphosphate

Disodium Cycloheptylaminomethylene Diphosphate

Product ID D3372
Cas No. 138330-18-4
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $100.70 In stock
100 mg $246.50 In stock
250 mg $503.40 In stock
Bulk Quote

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  • Description
  • Product Info
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  • References
  • Description
  • Product Info
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  • Downloads
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Description

Cycloheptylaminomethylene diphosphate is a bisphosphonate compound that inhibits squalene synthase and sterol biosynthesis in vitro and in vivo. In various immune cells, this compound increases caspase-mediated apoptosis. Like other bisphosphonates, this compound is known for its use in preventing bone resorption and bone loss. In vivo, this compound inhibits osteoclast-mediated bone resorption and prevents bone loss due to immobilization. When administered chronically, this compound delays fracture healing in vivo, but improves stiffness and ultimate load of the fractured bone; it does not prevent bone formation.

Product Info

Cas No.

138330-18-4

Purity

≥98%

Formula

C8H17NNa2O6P2

Formula Wt.

331.15

Chemical Name

disodium;[(cycloheptylamino)-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate

IUPAC Name

disodium;[2-cycloheptyl-1-[hydroxy(oxido)phosphoryl]ethyl]-hydroxyphosphinate

Synonym

Incadronate disodium hydrate, Bisphonal

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D3372 MSDS PDF

Info Sheet

D3372 Info Sheet PDF

References

Miwa A, Takezako N, Hayakawa H, et al. YM-175 induces apoptosis of human native monocyte-lineage cells via inhibition of prenylation. Am J Hematol. 2012 Dec;87(12):1084-8. PMID: 23044853.

Li C, Mori S, Li J, et al. Long-term effect of incadronate disodium (YM-175) on fracture healing of femoral shaft in growing rats. J Bone Miner Res. 2001 Mar;16(3):429-36. PMID: 11277259.

Li J, Mori S, Mashiba T, et al. Preadministration of incadronate disodium can prevent bone loss in rat proximal tibial metaphysis when induced by hindlimb immobilization by bandage. Bone. 1998 Nov;23(5):459-63. PMID: 9823453.

Gen M. Effects of bisphosphonates on vitamin A-induced bone resorption in thyroparathyroidectomized rat. Nihon Seikeigeka Gakkai Zasshi. 1995 Nov;69(11):1193-207. PMID: 8568374.

Amin D, Cornell SA, Gustafson SK, et al. Bisphosphonates used for the treatment of bone disorders inhibit squalene synthase and cholesterol biosynthesis. J Lipid Res. 1992 Nov;33(11):1657-63. PMID: 1464749.

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