Pemetrexed Disodium

Name: Pemetrexed Disodium
SKU: P1849
Availability: InStock

Product ID P1849

Cas No. 150399-23-8

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Pemetrexed is an antifolate anticancer chemotherapeutic that inhibits thymidylate synthase. Pemetrexed is currently in clinical trials as a potential treatment for ovarian cancer and lung adenocarcinoma. Pemetrexed may also inhibit other enzymes involved in folate metabolism, including serine hydroxymethyltransferase (SHMT), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). In vitro, Pemetrexed induces activation of caspases 2, 3, 8, and 9 and increases levels of Bax, Fas, death receptor 4 (DR4), and death receptor 5 (DR5), resulting in caspase-mediated apoptosis.

Product Info

Cas No.	150399-23-8
Purity	≥98%
Formula	C₂₀H₁₉N₅Na₂O₆
Formula Wt.	471.37
Chemical Name	disodium;(2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate
IUPAC Name	disodium;(2S)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2, 3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioate
Synonym	Alimta, Rolazar, Tifolar
Solubility	Water
Appearance	White to off white powder

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	P1849 MSDS PDF
Info Sheet	P1849 Info Sheet PDF

References

Walters CL, Arend RC, Armstrong DK, et al. Folate and folate receptor alpha antagonists mechanism of action in ovarian cancer. Gynecol Oncol. 2013 Nov;131(2):493-8. PMID: 23863359.

Lau DH, Moon J, Davies AM, et al. Southwestern oncology group phase II trial (S0526) of pemetrexed in bronchioloalveolar carcinoma subtypes of advanced adenocarcinoma. Clin Lung Cancer. 2013 Jul;14(4):351-5. PMID: 23415808.

Yang TY, Chang GC, Chen KC, et al. Pemetrexed induces both intrinsic and extrinsic apoptosis through ataxia telangiectasia mutated/p53-dependent and -independent signaling pathways. Mol Carcinog. 2013 Mar;52(3):183-94. PMID: 22086658.

Su L, Liu G, Hao X, et al. Death receptor 5 and cellular FLICE-inhibitory protein regulate pemetrexed-induced apoptosis in human lung cancer cells. Eur J Cancer. 2011 Nov;47(16):2471-8. PMID: 21726997.

Daidone F, Florio R, Rinaldo S, et al. In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed. Eur J Med Chem. 2011 May;46(5):1616-21. PMID: 21371789.

Joerger M, Omlin A, Cerny T, et al. The role of pemetrexed in advanced non small-cell lung cancer: special focus on pharmacology and mechanism of action. Curr Drug Targets. 2010 Jan;11(1):37-47. PMID: 19839929.

Blackwood E, Epler J, Yen I, et al. Combination drug scheduling defines a “window of opportunity” for chemopotentiation of gemcitabine by an orally bioavailable, selective ChK1 inhibitor, GNE-900. Mol Cancer Ther. 2013 Oct;12(10):1968-1980. PMID: 23873850.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Phone
This field is for validation purposes and should be left unchanged.

Pemetrexed Disodium

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Calcitonin, salmon

(+)-JQ-1

Regorafenib Monohydrate

Vindoline

PF-07104091

URB602

Palbociclib

Rufloxacin Hydrochloride

4’-Bromoflavone

Trimethoprim

PP-242

Angiotensin II (3-8), human

Veratridine

SMI-4a

11-Methoxyyangonin

Vapreotide

Proxymetacaine Hydrochloride

Dopamine Hydrochloride

Amylin (8-37), rat

INCB 28060 Hydrochloride Hydrate

Footer