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Telbivudine is an antiviral and immunomodulatory compound that is commonly used to treat chronic hepatitis B infections. Telbivudine is the L-isomer of thymidine and acts as a nucleoside analog. Clinically, telbivudine increases expression of CD127 on CD8+ memory T cells; this compound also decreases hepatitis B viral DNA and normalizes levels of alanine aminotransferase.
| Cas No. | 3424-98-4 |
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| Purity | ≥98% |
| Formula | C10H14N2O5 |
| Formula Wt. | 242.23 |
| IUPAC Name | 1-[(2S,4R, 5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione |
| Synonym | Epavudine, L-Thymidine, 1-(2-deoxy-β-L-ribofuranosyl)-5-methyluracil β-L-2-deoxythymidine β-L-thymidine (LdT) 1-[(2S,4R,5S)-4-hydroxy-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione |
| Appearance | White to off white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Nan XP, Zhang Y, Yu HT, et al. Inhibition of viral replication downregulates CD4(+)CD25(high) regulatory T cells and programmed death-ligand 1 in chronic hepatitis B. Viral Immunol. 2012 Feb;25(1):21-8. PMID: 22233255.
Lv G, Ying L, Ma WJ, et al. Dynamic analysis of CD127 expression on memory CD8 T cells from patients with chronic hepatitis B during telbivudine treatment. Virol J. 2010 Aug 31;7:207. PMID: 20807412.
Lai CL, Leung N, Teo EK, et al. A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen-positive chronic hepatitis B. Gastroenterology. 2005 Aug;129(2):528-36. PMID: 16083710.