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Benzimidazole is an organic compound that displays some anticancer benefit. Complexes of Cu(II) and benzimidazole bind to the minor groove of DNA, cleave supercoiled DNA, and inhibit topoisomerase I, inhibiting proliferation across several cancer cell lines. Additionally, benzimidazole derivatives are well known for their anti-parasitic, antifungal, and antibacterial activities. Benzimidazoles often inhibit microtubule polymerization.
| Cas No. | 51-17-2 |
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| Purity | ≥98% |
| Formula | C7H6N2 |
| Formula Wt. | 118.14 |
| Chemical Name | 1H-benzimidazole |
| IUPAC Name | 1H-benzimidazole |
| Synonym | 1H-Benzo[d]imidazole, Benzoimidazole |
| Melting Point | 170-172°C |
| Appearance | White to off white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Song WJ, Cheng JP, Jiang DH, et al. Synthesis, interaction with DNA and antiproliferative activities of two novel Cu(II) complexes with Schiff base of benzimidazole. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Oct 14;121C:70-76. PMID: 24220672
Molecular basis for benzimidazole resistance from a novel β-tubulin binding site model.
Aguayo-Ortiz R, Méndez-Lucio O, Romo-Mancillas A, Castillo R, Yépez-Mulia L, Medina-Franco JL, Hernández-Campos A.
J Mol Graph Model. 2013 Sep;45:26-37. PMID: 23995453.
Khabnadideh S, Rezaei Z, Pakshir K, et al. Synthesis and antifungal activity of benzimidazole, benzotriazole and aminothiazole derivatives. Res Pharm Sci. 2012 Apr;7(2):65-72. PMID: 23181082.
Arjmand F, Parveen S, Afzal M, et al. Synthesis, characterization, biological studies (DNA binding, cleavage, antibacterial and topoisomerase I) and molecular docking of copper(II) benzimidazole complexes. J Photochem Photobiol B. 2012 Sep 3;114:15-26. PMID: 22695227.