LKT Labs

Biochemicals for Life Science Research

Peimine

Peimine

Product ID P1634
Cas No. 23496-41-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $102.00 In stock
10 mg $163.40 In stock
25 mg $302.30 In stock
Bulk Quote

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Description

Peimine is a steroidal alkaloid found in a variety of species of the Fritillaria plant; it exhibits anti-inflammatory activity and acts as an expectorant and anti-tussive in cough medications. Peimine’s anti-tussive activity may result from negative potentiation of transient receptor potential channels TRPV1 and TRPA1 in vitro. Peimine inhibits cough frequency and cough latency in animal models. Additionally, peimine binds the DNA duplex, inhibits production of pro-inflammatory cytokines like TNF-α, IL-6, and IL-1β, and decreases expression of IκB kinase, JNK, and p38.

Product Info

Cas No.

23496-41-5

Purity

≥98%
Formula

C27H45NO3
Formula Wt.

431.65
Chemical Name

(1R,2S,6S,9S,10S,11S,14S,15S,17S,18S,20S,23R,24S)-6,10,23-trimethyl-4-azahexacyclo[12.11.0.02,11.04,9.015,24.018,23]pentacosane-10,17,20-triol
IUPAC Name

(1R,2S,6S,9S,10S,11S,14S,15S,17S,18S,20S,23R,24S)-6,10,23-trimethyl-4-azahexacyclo[12.11.0.02,11.04,9.015,24.018,23]pentacosane-10,17,20-triol
Synonym

Verticine, Wanpeinine A
Appearance

White Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

P1634 MSDS PDF
Info Sheet

P1634 Info Sheet PDF

References

Yi PF, Wu YC, Dong HB, et al. Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 2013 Oct;35(5):567-72. PMID: 23944357.

Ma L, Song F, Liu Z, et al. Study on noncovalent complexes of alkaloids with DNA duplex using electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom. 2013 Jan 15;27(1):51-8. PMID: 23239316.

Wang D, Zhu J, Wang S, et al. Antitussive, expectorant and anti-inflammatory alkaloids from Bulbus Fritillariae Cirrhosae. Fitoterapia. 2011 Dec;82(8):1290-4. PMID: 21958967.

Zhang Y, Sreekrishna K, Lin Y, et al. Modulation of transient receptor potential (TRP) channels by Chinese herbal extracts. Phytother Res. 2011 Nov;25(11):1666-70. PMID: 21432926.

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