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Peiminine is a steroidal alkaloid found in a variety of species of the Fritillaria plant; it acts as an expectorant and anti-tussive in cough medications. Peiminine increases cAMP, inhibits M2 mAChRs, and may negatively modulate transient receptor potential channels TRPV1 and TRPA1 in vitro. Peiminine also displays anti-inflammatory activity in animal models of pulmonary fibrosis, decreasing levels of IFN-γ, TGF-β, NF-κB, ERK1/2, and FasL.
| Cas No. | 18059-10-4 |
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| Purity | ≥98% |
| Formula | C27H43NO3 |
| Formula Wt. | 429.64 |
| Chemical Name | (1R,2S,6S,9S,10S,11S,14S,15S,18S,20S,23R,24S)-10,20-dihydroxy-6,10,23-trimethyl-4-azahexacyclo[12.11.0.02,11.04,9.015,24.018,23]pentacosan-17-one |
| IUPAC Name | (1R,2S,6S,9S,10S,11S,14S,15S,18S,20S,23R,24S)-10,20-dihydroxy-6,10,23-trimethyl-4-azahexacyclo[12.11.0.02,11.04,9.015,24.018,23]pentacosan-17-one |
| Synonym | Imperialine, verticinone, Fritillarine, Zhebeinone |
| Appearance | White Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
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| Info Sheet |
Guo H, Ji F, Liu B, et al. Peiminine ameliorates bleomycin-induced acute lung injury in rats. Mol Med Rep. 2013 Apr;7(4):1103-10. PMID: 23404624.
Zhang Y, Sreekrishna K, Lin Y, et al. Modulation of transient receptor potential (TRP) channels by Chinese herbal extracts. Phytother Res. 2011 Nov;25(11):1666-70. PMID: 21432926.
Zhou Y, Ji H, Lin BQ, et al. The effects of five alkaloids from Bulbus Fritillariae on the concentration of cAMP in HEK cells transfected with muscarinic M(2) receptor plasmid. Am J Chin Med. 2006;34(5):901-10. PMID: 17080553.