LKT Labs

Biochemicals for Life Science Research

PF-03758309 Dihydrochloride

PF-03758309 Dihydrochloride

Product ID P2000
Cas No. 1279034-84-2
Purity ≥99%, ≥99%ee
Product Unit SizeCostQuantityStock
1 mg $105.30 In stock
5 mg $180.30 In stock
25 mg $480.70 In stock
Bulk Quote

Quicklinks

Description

PF-03758309 is an ATP-competitive inhibitor of p21-activated kinase 4 (PAK4), a kinase typically upregulated in many cancers. This compound exhibits anticancer chemotherapeutic and anti-metastatic activities. Inhibition of PAK4 inhibits cell motility, proliferation, and survival in cellular models of cancer and suppresses tumor growth in animal models of cancer. PF-03758309 also inhibits fusion and migration of preosteoclasts, osteoclast differentiation, and podosome formation in cellular models of osteoclast-related disorders.

Product Info

Cas No.

1279034-84-2
Purity

≥99%, ≥99%ee
Formula

C25H30N8OS • 2HCl
Formula Wt.

563.55
IUPAC Name

N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide;hydrochloride
Synonym

PF-3758309 .2HCl
Solubility

Soluble in DMSO, water and alcohols.
Appearance

Off white to pale yellow powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

P2000 MSDS PDF
Info Sheet

P2000 Info Sheet PDF

References

Choi SW, Yeon JT, Ryu BJ, et al. Repositioning Potential of PAK4 to Osteoclastic Bone Resorption. J Bone Miner Res. 2015 Jan 31. [Epub ahead of print]. PMID: 25640698.

Ryu BJ, Lee H, Kim SH, et al. PF-3758309, p21-activated kinase 4 inhibitor, suppresses migration and invasion of A549 human lung cancer cells via regulation of CREB, NF-κB, and β-catenin signalings Mol Cell Biochem. 2014 Apr;389(1-2):69-77. PMID: 24366569.

Murray BW, Guo C, Piraino J, et al. Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9446-51. PMID: 20439741.

www.clinicaltrials.gov/show/NCT00932126

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • X4402

    XL-147

    Dual inhibitor of PI3K and mTOR.

    ≥98%
  • V0148

    Valproic Acid

    T-type Ca2+ and voltage-gated Na+ channel block...

    ≥98%
  • G7862

    GTPL-5846

    GPR84 agonist.

    ≥98%
  • T3038

    Thienylnonanyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥98%
  • H3277

    Histrelin Acetate

    Peptide, GnRH analog; GnRH agonist.
    ≥95%
  • P9767

    Pyriproxyfen

    Juvenile insect hormone mimic.

    ≥95%
  • G3354

    Ginkgolide A

    Terpene lactone found in Ginkgo; GSK-3β inhibi...

    ≥98%
  • D1757

    L-Deoxyalliin

    Organosulfur found in garlic.

    ≥98%
  • A5132

    Amikacin Disulfate

    Aminoglycoside; protein translation inhibitor.<...

    ≥98%
  • O7333

    OSI-906

    IGF-1R and InsR inhibitor.

    ≥98%
  • O0977

    Octopamine Hydrochloride

    Endogenous biogenic amine, norepinephrine-like ...

    ≥98%
  • T0119

    Taxol Side Chain β-lactam

    Taxol synthesis intermediate.

    ≥98%
  • U6802

    Urapidil Hydrochloride

    5-HT1A agonist, α1-adrenergic antagonist.

    ≥98%
  • A7204

    AS-605240

    p110δ PI3K inhibitor.

    ≥98%
  • E6432

    (−)-Epinephrine

    Active isomer of epinephrine, endogenous hormon...

    ≥98%
  • H9814

    25-Hydroxyvitamin D2

    Vitamin D2, ergocalciferol metabolite; VDR agon...

    ≥98%
  • F4556

    Florfenicol

    Synthetic fluorinated thiamphenicol analog; pro...

    ≥98%
  • C4758

    Closantel Sodium

    Protonophore; chitinase OvCHT1 inhibitor.

    ≥98%
  • A0910

    N-Acetyl-S-(N′-phenylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate, antioxidant.

    ≥98%
  • N7332

    NSI-189

    Stem cell neurogenesis inducer.

    ≥99%