LKT Labs

Biochemicals for Life Science Research

TG100-115

Product ID T2402
Cas No. 677297-51-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $138.90 In stock
5 mg $277.70 In stock
10 mg $447.90 In stock
Bulk Quote

Quicklinks

Description

TG100-115 is an inhibitor of p110δ PI3K and p110γ PI3K that exhibits anti-inflammatory and anti-asthma activities. TG100-115 decreases pulmonary eosinophil levels and accumulation of IL-13 and mucin in animal models of asthma and chronic obstructive pulmonary disorder (COPD), decreasing inflammation. TH100-115 also inhibits edema and inflammation induced by VEGF and platelet activating factor (PAF) in other animal models, decreasing development of infarcts and improving cardiac function. As a result of its cardioprotective activity, TG100-115 is currently in clinical trials as a potential treatment to reduce acute myocardial infarctions.

Product Info

Cas No.

677297-51-7
Purity

≥98%
Formula

C18H14N6O2
Formula Wt.

346.34
IUPAC Name

3-[2,4-diamino-7-(3-hydroxyphenyl)pteridin-6-yl]phenol
Solubility

DMSO 9 mg/mL (25.98 mM) Water Insoluble Ethanol Insoluble
Appearance

Yellow-Tan Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

T2402 MSDS PDF
Info Sheet

T2402 Info Sheet PDF

References

Doukas J, Eide L, Stebbins K, et al. Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease. J Pharmacol Exp Ther. 2009 Mar;328(3):758-65. PMID: 19056934.

Doukas J, Wrasidlo W, Noronha G, et al. Isoform-selective PI3K inhibitors as novel therapeutics for the treatment of acute myocardial infarction. Biochem Soc Trans. 2007 Apr;35(Pt 2):204-6. PMID: 17371238.

Doukas J, Wrasidlo W, Noronha G, et al. Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19866-71. PMID: 17172449.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • R5774

    Roscovitine

    CDK inhibitor, L-type Ca2+ channel blocker.

    ≥98%
  • E7556

    Etodolac

    NSAID; TRPA1 agonist, COX-2 inhibitor.

    ≥98%
  • D0004

    Dabrafenib

    B-Raf and c-Raf inhibitor.

    ≥98%
  • T3040

    Thienylpentyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥98%
  • N4974

    NMS-E628

    ALK and Ros1 inhibitor, Trk antagonist.

    ≥98%
  • G1651

    Geniposidic Acid

    Iridoid glucoside found in Eucommia, Castilleja...

    ≥98%
  • P1634

    Peimine

    Steroidal alkaloid found in Fritillaria; TRPV1 ...

    ≥98%
  • C4658

    Clopidogrel Sulfate

    Thienopyridine; P2Y12 antagonist.

    ≥98%
  • S6233

    Spiramycin Hexanedioate

    Macrolide; protein synthesis inhibitor.

    ≥90%
  • S3470

    Sirtinol

    Sirtuin inhibitor and iron chelator.

    ≥98%
  • A0961

    Adrenocorticotropic Hormone (1-39), rat

    Endogenous peptide hormone, involved in stress ...

    ≥95%
  • D3353

    Diminazene Aceturate

    Diamidine; ACE2 activator, DNA polymerase inhib...

    ≥98%
  • Z7477

    ZSTK474

    PI3K inhibitor.

    ≥98%
  • T1674

    Terbutaline Sulfate

    β2-adrenergic agonist, potential ENaC activato...

    ≥98%
  • D336486

    Dimethylamino Parthenolide

    Water-soluble parthenolide analog; NF-κB inhib...

    ≥98%
  • B030967

    BAY-1895344

    ATR inhibitor.

    ≥99%
  • C1718

    Cepharanthine, 95%

    Alkaloid found in Stephania.

    ≥95%
  • G2969

    Growth Hormone Releasing Hexapeptide

    Synthetic peptide hormone, met-enkephalin analo...

    ≥95%
  • M1335

    Mdivi-1

    Quinazolinone; mitochondrial division inhibitor...

    ≥98%
  • P200097

    PF-06821497

    EZH2 inhibitor

    ≥99%