LKT Labs

Biochemicals for Life Science Research

Staurosporine

Staurosporine

Product ID S7600
Cas No. 62996-74-1
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $45.50 In stock
5 mg $162.30 In stock
25 mg $389.40 In stock
100 mg $973.40 In stock
Bulk Quote

Quicklinks

Description

Staurosporine is an alkaloid initially produced by Streptomyces that inhibits PKC and other protein kinases. Staurosporine is a precursor in the synthesis of kinase inhibitors K252c and PKC412. This compound exhibits anticancer, anti-parasitic, and anti-protozoan activities. Staurosporine induces apoptosis in hepatocarcinoma cells by decreasing levels of p38 MAPK, pERK, and DNA methyltransferase 3B (DNMT 3B) and increasing levels of pJNK. Staurosporine also causes cell death in Trypanosoma. This compound also inhibits mammalian RNA splicing.

Product Info

Cas No.

62996-74-1
Purity

≥98%
Formula

C28H26N4O3
Formula Wt.

466.5
IUPAC Name

(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one
Synonym

AM-2282
Melting Point

237-239°C
Solubility

Soluble in DMSO (50 mM), ethanol, or methanol (2 mg/mL). Insoluble in water.

Appearance

Off-white Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

S7600 MSDS PDF
Info Sheet

S7600 Info Sheet PDF

References

Zhao C, Yin P, Mei C, et al. Down-regulation of DNA methyltransferase 3B in staurosporine-induced apoptosis and its mechanism in human hepatocarcinoma cell lines. Mol Cell Biochem. 2013 Apr;376(1-2):111-9. PMID: 23397112.

Bruges G, Betancourt M, March M, et al. Apoptotic-like activity of staurosporine in axenic cultures of Trypanosoma evansi. Rev Inst Med Trop Sao Paulo. 2012 Mar-Apr;54(2):103-8. PMID: 22499424.

Aukema KG, Chohan KK, Plourde GL, et al. Small molecule inhibitors of yeast pre-mRNA splicing. ACS Chem Biol. 2009 Sep 18;4(9):759-68. PMID: 19634919.

Tanramluk D, Schreyer A, Pitt WR, et al. On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine. Chem Biol Drug Des. 2009 Jul;74(1):16-24. PMID: 19519740.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A5326

    Aniracetam

    AMPA positive allosteric modulator, D2, 5-HT2A,...

    ≥98%
  • C5771

    Corticosterone

    Endogenous steroid hormone involved in immune r...

    ≥98%
  • A6826

    L-Arginine Hydrochloride

    Endogenous amino acid, also found in meat, dair...

    ≥98%
  • T3203

    Tianeptine Sodium Hydrate

    μOR and δOR agonist, D2/D3 DA potentiator.

    ≥98%
  • A9914

    AZD-8055

    mTOR inhibitor.

    ≥98%
  • I7457

    1-Isothiocyanato-6-(methylsulfinyl)-hexane

    Synthetic derivative of 6-methylsulfinyl-hexane...

    ≥98%
  • S3346

    Silodosin

    α1A-adrenergic antagonist.

    ≥98%
  • J291331

    JH-II-127

    Selective inhibitor of LRRK2.

    ≥98%
  • T6903

    Tranylcypromine Hydrochloride

    MAO and histone demethylase LSD1 inhibitor.

    ≥98%
  • T5846

    Tolfenamic Acid

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • N7208

    NSC-74859

    STAT3 inhibitor.

    ≥98%
  • S0500

    SB-203580

    p38 MAPK inhibitor.

    ≥98%
  • C4000

    CK-636

    Arp2/3 inhibitor.

    ≥98%
  • A965121

    AZD-5438

    Inhibitor of CDK.

    ≥98%
  • A5373

    Anisomycin

    Peptidyl transferase inhibitor, protein transla...

    ≥98%
  • P982691

    Pyridostatin Trifluoroacetate Salt

    G-quadruplex ligand; DNA breakage inducer.

    ≥95%
  • D0368

    2-Epi-16-deoxysarcophine

    Cembranoid found in Sarcophyton.

    ≥98%
  • T2833

    1-Thio-β-D-glucose Tetraacetate

    Imaging agent; Maillard reaction inhibitor.

    ≥98%
  • A2077

    Afatinib

    EGFR inhibitor.

    ≥98%
  • A2401

    AG-18

    EGFR and PDGFR inhibitor

    ≥98%