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α-Zearalenol is a mycotoxin that has structural similarity to estrogen and can bind to estrogen receptors. α-Zearalenol is one of the major metabolites of zearalenone, which is produced by several species of Fusarium and is known to induce many toxic effects. In cultured cells, α-Zearalenol was shown to inhibit cell viability, protein and DNA syntheses, and to induce oxidative damage.
| Cas No. | 36455-72-8 |
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| Purity | ≥98% |
| Formula | C18H24O5 |
| Formula Wt. | 320.39 |
| IUPAC Name | (4~{S},8~{R},12~{E})-8,16,18-trihydroxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),12,15,17-tetraen-2-one |
| Synonym | Alpha-Zearalenol; Trans-Zearalenol; Cis-Zearalenol; Zearalenol; (3R,7R,11E)-7,14,16-trihydroxy-3-methyl-3,4,5,6,7,8,9,10-octahydro-1H-2-benzoxacyclotetradecin-1-one; 1H-2-benzoxacyclotetradecin-1-one, 3,4,5,6,7,8,9,10-octahydro-7,14,16-trihydroxy-3-methyl-, (3S,7R,11E)-; 3,4,5,6,7,8,9,10-octahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Tatay E, Espin S, Garcia-Fernandez AJ, et al. Estrogenic activity of zearalenone, α-Zearalenol and β-Zearalenol assessed using the E-screen assay in MCF-7 cells. Toxicol Mech Methods. 2018 May;28(4):239-242. PMID: 29057713.
Ben Salem I, Boussabbeh M, Pires Da Silva J, et al. SIRT1 protects cardiac cells against apoptosis induced by zearalenone or its metabolites α-Zearalenol and β-Zearalenol through an autophagy-dependent pathway. Toxicol Appl Pharmacol. 2017 Jan 1;314:82-90. PMID: 27889531.
Othmen ZO, Golli EE, Abid-Essefi S, et al. Cytotoxicity effects induced by zearalenone metabolites, alpha zearalenol and beta zearalenol, on cultured Vero cells. Toxicology. 2008 Oct 30;252(1-3):72-77. PMID: 18755238.
