LKT Labs

Biochemicals for Life Science Research

(−)-Bilobalide

Product ID B3345
Cas No. 33570-04-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $64.90 In stock
10 mg $116.60 In stock
25 mg $268.80 In stock
Bulk Quote

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Description

Bilobalide is a sesquiterpene lactone found in Ginkgo that exhibits neuroprotective, cognition enhancing, anxiolytic, antioxidative, anti-inflammatory, and analgesic activities. Bilobalide inhibits GABA-A receptors, decreases anxiety, and improves spatial learning and memory in vivo. In animal models of cerebral ischemia/reperfusion, bilobalide decreases edema and infarct volume. In adipocytes, this compound inhibits hypoxia-induced oxidative stress and inflammation. Additionally, bilobalide inhibits carrageenan- and capsaicin-induced hyperalgesia in animal models.

Product Info

Cas No.

33570-04-6
Purity

≥98%
Formula

C15H18O8
Formula Wt.

326.30
Chemical Name

(5aR-(3aS,5aα,8b,8aS,9a,10aα))-9-(1,1-dimethylethyl)- 10,10a-dihydro-8,9-dihydroxy-4H,5aH,9H-furo[2,3-b]furo[3',2':2,3]cyclopenta[1,2-c]furan-2,4,7(3H,8H)- trione
Synonym

Bilobalide
Melting Point

300°C
Solubility

Soluble in ethanol or DMSO.
Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

B3345 MSDS PDF
Info Sheet

B3345 Info Sheet PDF

References

A P, V M N, S S A, et al. Bilobalide attenuates hypoxia induced oxidative stress, inflammation, and mitochondrial dysfunctions in 3T3 L1 adipocytes via its antioxidant potential. Free Radic Res. 2014 Jul 21:1-31. PMID: 25039303.

Goldie M, Dolan S. Bilobalide, a unique constituent of Ginkgo biloba, inhibits inflammatory pain in rats. Behav Pharmacol. 2013 Aug;24(4):298-306. PMID: 23838965.

Ma L, Wang S, Tai F, et al. Effects of bilobalide on anxiety, spatial learning, memory and levels of hippocampal glucocorticoid receptors in male Kunming mice. Phytomedicine. 2012 Dec 15;20(1):89-96. PMID: 23083816.

Defeudis FV. Bilobalide and neuroprotection. Pharmacol Res. 2002 Dec;46(6):565-8. PMID: 12457632.

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