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17-α-Ethynylestradiol

17-α-Ethynylestradiol

Product ID E7731
Cas No. 57-63-6, 77538-56-8, 406932-93-2, 1050678-65-3
Purity ≥99%
Product Unit SizeCostQuantityStock
1 g $81.00 In stock
5 g $359.20 In stock
10 g $574.80 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • Downloads
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  • Custom Order

Description

17-α-ethynylestradiol is a synthetic estrogen receptor (ER) agonist clinically used in contraceptive medications. In pregnant rats, 17-α-ethynylestradiol decreases platelet activating factor acetylhydrolase activity, inducing premature birth. 17-α-ethynylestradiol also displays weak antioxidative activity in lipid peroxidation assays in liver microsomes. Both acute and chronic exposure of wildlife (particularly fish) to 17-α-ethynylestradiol leads to feminization of males (through the induction of vitellogenin production), inhibiting fertility.

Product Info

Cas No.

57-63-6, 77538-56-8, 406932-93-2, 1050678-65-3

Purity

≥99%

Formula

C20H24O2

Formula Wt.

296.40

Chemical Name

(8R,9S,13S,14S,17R)-17-ethynyl-13-methyl-7,8,9,11,12,14,15, 16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol

IUPAC Name

(8R,9S,13S,14S,17R)-17-ethynyl-13-methyl-7,8,9,11,12,14,15, 16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol

Synonym

Ethinylestradiol

Melting Point

182-183°C

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

E7731 MSDS PDF

Info Sheet

E7731 Info Sheet PDF

References

Kidd KA, Blanchfield PJ, Mills KH, et al. Collapse of a fish population after exposure to a synthetic estrogen. Proc Natl Acad Sci U S A. 2007 May 22;104(21):8897-901. PMID: 17517636.

Schultz IR, Skillman A, Nicolas JM, et al. Short-term exposure to 17 alpha-ethynylestradiol decreases the fertility of sexually maturing male rainbow trout (Oncorhynchus mykiss). Environ Toxicol Chem. 2003 Jun;22(6):1272-80. PMID: 12785584.

Yasuda K, Furukawa M, Johnston JM. Effect of estrogens on plasma platelet-activating factor acetylhydrolase and the timing of parturition in the rat. Biol Reprod. 1996 Jan;54(1):224-9. PMID: 8838020.

Lacort M, Leal AM, Liza M, et al. Protective effect of estrogens and catecholestrogens against peroxidative membrane damage in vitro. Lipids. 1995 Feb;30(2):141-6. PMID: 7769970.

Custom Order

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