• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
18β-Glycyrrhetinic Acid

18β-Glycyrrhetinic Acid

Product ID G4597
Cas No. 471-53-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $84.10 In stock
10 g $138.30 In stock
25 g $252.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

18β-Glycyrrhetinic Acid (enoxolone) is a triterpene glycoside found in Glycyrrhiza that exhibits anti-hyperlipidemic, anti-obesity, anti-inflammatory, anticancer, and anti-metastatic activities. Enoxolone is commercially used as a flavorant. Enoxolone inhibits 15-hydroxyprostaglandin dehydrogenase, altering the metabolism of prostaglandins E2 (PGE2) and F2 (PGF2). Enoxolone also modulates ion channel activity, inhibiting human ether-related-a-go-go (hERG) K+ channels and Kv1.3 K+ channels. In vitro, enoxolone prevents production of IL-2 and activation of T cells. In other cellular models, enoxolone decreases cellular invasion, expression of matrix metalloproteinase 9 (MMP9) and VEGF, and activity of NF-κB. This compound also induces apoptosis in non-small cell lung cancer (NSCLC) cells, decreasing expression of Bcl-2, Bcl-xl, cyclin D1, and cyclin E, increasing activation of caspases and PARP, and downregulating phosphorylation of JNK and PKC. In animal models, enoxolone inhibits anandamide-induced adipocyte differentiation, suppresses expression of fatty acid synthase, and decreases plasma lipid levels, fat weight, and body weight.

Product Info

Cas No.

471-53-4

Purity

≥98%

Formula

C30H46O4

Formula Wt.

470.68

Chemical Name

(3β,20β)-3-Hydroxy-11-oxoolean-12-en-29-oic acid

IUPAC Name

(2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-hydroxy-2,4a,6a,6b,9,9, 12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12, 14b-dodecahydro-1H-picene-2-carboxylic acid

Synonym

Enoxolone, Uralenic acid, Arthrodont, Biosone

Melting Point

296°C

Solubility

Soluble in ethanol, chloroform, dioxone, pyridine or acetic acid.

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

G4597 MSDS PDF

Info Sheet

G4597 Info Sheet PDF

References

Jayasooriya RG, Dilshara MG, Park SR, et al. 18β-Glycyrrhetinic acid suppresses TNF-α induced matrix metalloproteinase-9 and vascular endothelial growth factor by suppressing the Akt-dependent NF-κB pathway. Toxicol In Vitro. 2014 Aug;28(5):751-8. PMID: 24613819.

Park M, Lee JH, Choi JK, et al. 18β-glycyrrhetinic acid attenuates anandamide-induced adiposity and high-fat diet induced obesity. Mol Nutr Food Res. 2014 Jul;58(7):1436-46. PMID: 24687644.

Song J, Ko HS, Sohn EJ, et al. Inhibition of protein kinase C α/βII and activation of c-Jun NH2-terminal kinase mediate glycyrrhetinic acid induced apoptosis in non-small cell lung cancer NCI-H460 cells. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1188-91. PMID: 24461294.

Wu D, Jiang L, Wu H, et al. Inhibitory effects of glycyrrhetinic Acid on the delayed rectifier potassium current in Guinea pig ventricular myocytes and HERG channel. Evid Based Complement Alternat Med. 2013;2013:481830. PMID: 24069049.

Fu XX, Du LL, Zhao N, et al. 18β-Glycyrrhetinic acid potently inhibits Kv1.3 potassium channels and T cell activation in human Jurkat T cells. J Ethnopharmacol. 2013 Jul 9;148(2):647-54. PMID: 23707333.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C1869

    Cerulenin

    Found in Cephalosporium; fatty acid synthase in...

    ≥98%
  • I7746

    1-Isothiocyanato-7-(methylsulfenyl)-heptane

    ITC, erucin analog.

    ≥98%
  • H1862

    Heptaplatin

    Pt-based DNA cross-linker.

    ≥98%
  • D3214

    2′,3′-Dideoxyinosine

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%
  • C1633

    Cefotaxime Sodium

    β-lactam cephalosporin; penicillin binding pro...

    ≥96%
  • M3310

    Miconazole Nitrate

    Imidazole; 14-α demethylase inhibitor, potenti...

    ≥98%
  • M0273

    Mastoparan 8

    Antimicrobial peptide found in bee and wasp ven...

    ≥95%
  • A7333

    Asiaticoside

    Triterpene found in Centella, prevents melanoge...

    ≥90%
  • T6934

    Trimebutine Maleate

    L-type Ca2+ channel blocker, BK K+ channel modu...

    ≥96%
  • V3251

    Vinorelbine Base

    Semi-synthetic vinca alkaloid found in Catharan...

    ≥90%
  • B3300

    BI-6727

    PLK1 inhibitor.

    ≥99%
  • G3461

    Ginsenoside F2

    Triterpene saponin found in species of Panax.

    ≥98%
  • M3353

    Minocycline Hydrochloride

    Tetracycline; protein translation inhibitor, MM...

    ≥98%
  • I6804

    Irbesartan

    PPARγ agonist, AT1 inhibitor.

    ≥98%
  • A0501

    Abamectin

    Macrocyclic lactone avermectin; GABA antagonist...

    ≥70%
  • E8419

    Everolimus

    mTORC1 inhibitor.

    ≥98%
  • B8176

    2-n-Butylthiophene

    Sulfur analog of furan found in cooked meat pro...

    ≥98%
  • O9396

    Oxytetracycline

    Tetracycline; protein translation inhibitor.

    ≥96%
  • E325127

    EIDD-1931

    Broad-spectrum antiviral activity against SARS-...

    ≥99%
  • N0161

    β-Naphthoflavone

    AhR agonist.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only