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AZT is a thymidine nucleoside analog that inhibits reverse transcriptase and is clinically used to treat HIV/AIDS. AZT inhibits viral DNA synthesis, preventing viral replication; at high doses, it may inhibit DNA polymerase. Use of AZT is often limited by hepatotoxicity and steatosis.
| Cas No. | 30516-87-1 |
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| Purity | ≥98% |
| Formula | C10H13N5O4 |
| Formula Wt. | 267.24 |
| Chemical Name | 1-[4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methyl- pyrimidine-2,4-dione |
| IUPAC Name | 1-[(2R,4S, 5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione |
| Synonym | AZT, Azidothymidine, Zidovudine, ZDV, ZVD |
| Melting Point | 118-126°C |
| Solubility | Soluble in water (50mg/mL). |
| Appearance | Off-white crystalline powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Banerjee A, Abdelmegeed MA, Jang S, et al. Zidovudine (AZT) and hepatic lipid accumulation: implication of inflammation, oxidative and endoplasmic reticulum stress mediators. PLoS One. 2013 Oct 11;8(10):e76850. PMID: 24146933.
Parker WB, White EL, Shaddix SC, et al. Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymerases alpha, beta, and gamma by the 5'-triphosphates of carbovir, 3'-azido-3'-deoxythymidine, 2',3'-dideoxyguanosine and 3'-deoxythymidine. A novel RNA template for the evaluation of antiretroviral drugs. J Biol Chem. 1991 Jan 25;266(3):1754-62. PMID: 1703154.
Furman PA, Fyfe JA, St Clair MH, et al. Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase. Proc Natl Acad Sci U S A. 1986 Nov;83(21):8333-7. PMID: 2430286.