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6-hydroxydopamine is a neurotoxin frequently used to aid in modeling Parkinson’s disease in rodents. For example, a recent study using safinamide in rats that were previously injected with 6-hydroxydopamine demonstrated its neuroprotective potential.
| Cas No. | 636-00-0 |
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| Purity | ≥98% |
| Formula | C8H12BrNO3 |
| Formula Wt. | 250.09 |
| IUPAC Name | 5-(2-Aminoethyl)-1,2,4-benzenetriol hydrobromide (1:1) |
| Synonym | Hydroxydopamine HBr, Oxidopamine, 2,4,5-Trihydroxyphenethylamine, 6-OHDA |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Simola N., Morelli M., et al. The 6-hydroxydopamine model of Parkinson's disease. Neurotox Res. 11(3-4):151-67 (2007). PMID: 17449457.
Sadeghian M., Mullali G., et al. Neuroprotection by safinamide in the 6-hydroxydopamine model of Parkinson's disease. Neuropathol Appl Neurobiol. 42(5):423-35 (2016). PMID: 26300398.