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A23187 Ca-Mg

A23187 Ca-Mg

Product ID A0102
Cas No.
Purity ≥98%, TLC
Product Unit SizeCostQuantityStock
5 mg $152.40 In stock
10 mg $281.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

A23187 is a Ca2+ ionophore that exhibits pro-inflammatory and allergic activities. In cardiomyocytes, A23187 induces formation of endothelial microvesicles, increasing leakage of lactate dehydrogenase and decreasing cell viability. A23187 also induces mast cell degranulation and increases production of TNF-α. In spermatozoa, this compound induces the acrosome reaction, allowing fertilization to occur in the absence of PKA activation.

Product Info

Purity

≥98%, TLC

Formula

(C29H36N3O6)2Mg • (C29H36N3O6)2Ca

Formula Wt.

523.62

Synonym

Calcium-magnesium salt of A23187, Calcium-magnesium salt of calcimycin.

Melting Point

230°-250°C. (dec)

Solubility

Insoluble in water, hexane. Slightly soluble in ethanol, methanol. Soluble in choloform, acetone.

Appearance

White Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

A0102 MSDS PDF

Info Sheet

A0102 Info Sheet PDF

References

Kim DY, Kang TB, Shim DW, et al. Emodin attenuates A23187-induced mast cell degranulation and tumor necrosis factor-α secretion through protein kinase C and IκB kinase 2 signaling. Eur J Pharmacol. 2014 Jan 15;723:501-6. PMID: 24239713.

Shang M, Zhang Q, Zhang MX, et al. Effects of endothelial microvesicles induced by A23187 on H9c2 cardiomyocytes. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013 Nov;29(6):559-64. PMID: 24654540.

Tateno H, Krapf D, Hino T, et al. Ca2+ ionophore A23187 can make mouse spermatozoa capable of fertilizing in vitro without activation of cAMP-dependent phosphorylation pathways. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18543-8. PMID: 24128762.

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