• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
A66

A66

Product ID A0002
Cas No. 1166227-08-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $142.10 In stock
5 mg $400.90 In stock
10 mg $683.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

A66 is an inhibitor of p110α PI3K that exhibits anticancer chemotherapeutic activity. A66 decreases cell viability of endometrial cancer cells and inhibits tumor growth of xenografts when administered in combination with other therapies. In animal models, A66 increases glucose output and impairs glucose and insulin tolerance.

Product Info

Cas No.

1166227-08-2

Purity

≥98%

Formula

C17H23N5O2S2

Formula Wt.

393.53

IUPAC Name

(2S)-1-N-[5-(2-tert-butyl-1,3-thiazol-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide

Solubility

20mg/ml in DMSO insoluble in water

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A0002 MSDS PDF

Info Sheet

A0002 Info Sheet PDF

Brochures

PI3K-Akt-mTORC Pathway Booklet

References

Weigelt B, Warne PH, Lambros MB, et al. PI3K pathway dependencies in endometrioid endometrial cancer cell lines. Clin Cancer Res. 2013 Jul 1;19(13):3533-44. PMID: 23674493.

Smith GC, Ong WK, Rewcastle GW, et al. Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo. Biochem J. 2012 Feb 15;442(1):161-9. PMID: 22142257.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • O6953

    Ornidazole

    5-Nitroimidazole derivative; genotoxic.

    ≥98%
  • A965121

    AZD-5438

    Inhibitor of CDK.

    ≥98%
  • M1687

    Mevinolin

    Statin, naturally produced by mushrooms; HMG-Co...

    ≥97%
  • C5618

    Coelenterazine, natural

    Light-emitting luciferin analog found in aquati...

    ≥98%
  • L5822

    Lofexidine Hydrochloride

    α2-adrenergic agonist.

    ≥98%
  • T1968

    Terpinen-4-ol

    Monoterpene found in various plant sources.

    ≥98%
  • D1792

    Dextromethorphan Hydrobromide Hydrate

    σ1/2and μ/κ/δ-OR agonist, α3β4/α4β2/α7...

    ≥98%
  • A985134

    AZD-9291

    EGFR inhibitor.

    ≥99%
  • P7034

    Prion Peptide (106-126), human

    Synthetic peptide fragment, prion protein analo...

    ≥95%
  • A3208

    AICAR

    AMPK activator.

    ≥98%
  • E4668

    ELR-510444

    Microtubule polymerization inhibitor.

    ≥98%
  • T0097

    10-Deacetyltaxol B

    Diterpene found in Taxus; potential microtubule...

    ≥98%
  • A5001

    Aminopterin

    Folic acid analog, derivative of pterin; dihydr...

    ≥98%
  • N176498

    Nemorosone

    Found in the propolis of honey bees.

    ≥99%
  • B0245

    Balicatib

    Cathepsin K inhibitor.

    ≥98%
  • E537333

    Enniatin A1

    Mycotoxin contaminant found in cereal grains.

    ≥98%
  • T6934

    Trimebutine Maleate

    L-type Ca2+ channel blocker, BK K+ channel modu...

    ≥96%
  • M2408

    MGCD-265 Analog

    MET inhibitor.

    ≥98%
  • A5277

    Angiotensin II, human

    Endogenous peptide, involved in vasoconstrictio...

    ≥95%
  • T3096

    Thymosin α-1

    Endogenous peptide fragment, immunostimulant; ...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only