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A66

A66

Product ID A0002
Cas No. 1166227-08-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $142.10 In stock
5 mg $400.90 In stock
10 mg $683.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

A66 is an inhibitor of p110α PI3K that exhibits anticancer chemotherapeutic activity. A66 decreases cell viability of endometrial cancer cells and inhibits tumor growth of xenografts when administered in combination with other therapies. In animal models, A66 increases glucose output and impairs glucose and insulin tolerance.

Product Info

Cas No.

1166227-08-2

Purity

≥98%

Formula

C17H23N5O2S2

Formula Wt.

393.53

IUPAC Name

(2S)-1-N-[5-(2-tert-butyl-1,3-thiazol-4-yl)-4-methyl-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide

Solubility

20mg/ml in DMSO insoluble in water

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A0002 MSDS PDF

Info Sheet

A0002 Info Sheet PDF

Brochures

PI3K-Akt-mTORC Pathway Booklet

References

Weigelt B, Warne PH, Lambros MB, et al. PI3K pathway dependencies in endometrioid endometrial cancer cell lines. Clin Cancer Res. 2013 Jul 1;19(13):3533-44. PMID: 23674493.

Smith GC, Ong WK, Rewcastle GW, et al. Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo. Biochem J. 2012 Feb 15;442(1):161-9. PMID: 22142257.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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