Description
Abacavir is a guanosine nucleoside analog reverse transcriptase inhibitor (NRTI) that is clinically used to treat HIV infection. Abacavir exhibits antiviral activity. This compound also inhibits guanylyl cyclase and telomerase activity.
Abacavir
Product ID A0401
Cas No. 136470-78-5
Purity ≥98%
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Product Info
| Cas No. | 136470-78-5 |
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| Purity | ≥98% |
| Formula | C14H18N6O |
| Formula Wt. | 286.33 |
| IUPAC Name | [(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol |
| Solubility | H2O: ≥17 mg/mL DMSO 78 mg/mL Ethanol <1mg/mL |
| Appearance | White to off white powder |
Shipping and Storage
| Store Temp | Ambient |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet | |
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References
Cardone M, Baghdassarian H, Khalaj M, et al. Insights into regulatory T-cell and type-I interferon roles in determining abacavir-induced hypersensitivity or immune tolerance. Front Immunol. 2025 Jun 6:16:1612451. PMID: 40547023.
Leeansyah E, Cameron PU, Solomon A, et al. Inhibition of telomerase activity by human immunodeficiency virus (HIV) nucleos(t)ide reverse transcriptase inhibitors: a potential factor contributing to HIV-associated accelerated aging. J Infect Dis. 2013 Apr;207(7):1157-65. PMID: 23303810.
Baum PD, Sullam PM, Stoddart CA, et al. Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase. AIDS. 2011 Nov 28;25(18):2243-8. PMID: 21941165.
Ribera E, Tuset M, MartÃn M, et al. Characteristics of antiretroviral drugs. Enferm Infecc Microbiol Clin. 2011 May;29(5):362-91. PMID: 21531048.