ABT-737

Name: ABT-737
SKU: A0778
Availability: InStock

Product ID A0778

Cas No. 852808-04-9

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

ABT-737 is a BH3 mimetic that acts as an inhibitor of Bcl-2, Bxl-xl, and Bcl-ω. ABT-737 exhibits anticancer chemotherapeutic and antithrombotic activities. ABT-737 is currently in clinical trials as one component of a combination therapy in the treatment of various cancers such as acute myelogenous leukemia (AML). This compound inhibits growth of AML cells in vitro and increases survival rates and lifespan in animal models of AML. In vitro, ABT-737 induces mitochondrial membrane depolarization in platelets, inducing apoptosis and clearance.

Product Info

Cas No.	852808-04-9
Purity	≥98%
Formula	C₄₂H₄₅ClN₆O₅S₂
Formula Wt.	813.43
IUPAC Name	4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonylbenzamide
Synonym	ABT737
Solubility	DMSO 100 mg/mL (122.93 mM) Water Insoluble Ethanol Insoluble
Appearance	Yellow powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	A0778 MSDS PDF
Info Sheet	A0778 Info Sheet PDF

References

Lieber J, Armeanu-Ebinger S, Fuchs J. The Role of BH3-Mimetic Drugs in the Treatment of Pediatric Hepatoblastoma. Int J Mol Sci. 2015 Feb 16;16(2):4190-4208. PMID: 25690034.

Baev DV, Krawczyk J, O’Dwyer M, et al. The BH3-mimetic ABT-737 effectively kills acute myeloid leukemia initiating cells. Leuk Res Rep. 2014 Sep 1;3(2):79-82. PMID: 25379408.

Gyulkhandanyan AV, Mutlu A, Allen DJ, et al. BH3-mimetic ABT-737 induces strong mitochondrial membrane depolarization in platelets but only weakly stimulates apoptotic morphological changes, platelet shrinkage and microparticle formation. Thromb Res. 2014 Jan;133(1):73-9. PMID: 24268298.

Beurlet S, Omidvar N, Gorombei P, et al. BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells. Blood. 2013 Oct 17;122(16):2864-76. PMID: 23943652.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Phone
This field is for validation purposes and should be left unchanged.

ABT-737

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Aureothricin

Atriopeptin II, rat/rabbit/mouse

Tebuconazole

N-Nitroso Bumetanide

Chloramphenicol

Triacetyl Aloe-emodin (Impurity A)

Tofacitinib Citrate

Penicillin G procaine

Tirasemtiv

Daidzein

PIK-75

DU-14

Dacomitinib Anhydrous

Enalapril Maleate

Thymosin α-1

Sesamin

JW55

5-Aminopyrimidine

Thienylheptyl Isothiocyanate

GSK-1120212

Footer