• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
ADX-47273

ADX-47273

Product ID A1592
Cas No. 851881-60-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $97.70 In stock
5 mg $339.50 In stock
25 mg $1,208.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

ADX 47273 is a positive allosteric modulator of metabotropic glutamate receptor mGluR5 that displays antipsychotic, neuromodulatory, and cognition enhancing activities. In vivo, ADX 47273 increases waking and decreases deep sleep behaviors; it also increases late phase long-term potentiation (LTP) and enhances adaptive learning. In other animal models, ADX 47273 decreases amphetamine- and phencyclidine-induced hyperlocomotion and accumbal dopamine levels.

Product Info

Cas No.

851881-60-2

Purity

≥98%

Formula

C20H17F2N3O2

Formula Wt.

369.36

Chemical Name

Piperidine, 1-(4-fluorobenzoyl)-3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)-, (3S)-

IUPAC Name

(4-fluorophenyl)-[(3S)-3-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]methanone

Synonym

ADX 47273; ADX47273; UNII-4C4P7L0W63; CHEMBL381055; J-502326

Solubility

DMSO 74 mg/mL Ethanol 30 mg/mL Water Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A1592 MSDS PDF

Info Sheet

A1592 Info Sheet PDF

References

Ahnaou A, Langlois X, Steckler T, et al. Negative versus positive allosteric modulation of metabotropic glutamate receptors (mGluR5): indices for potential pro-cognitive drug properties based on EEG network oscillations and sleep-wake organization in rats. Psychopharmacology (Berl). 2015 Mar;232(6):1107-22. PMID: 25323624.

Xu J, Zhu Y, Kraniotis S, et al. Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning. Learn Mem. 2013 Jul 18;20(8):438-45. PMID: 23869026.

Kroker KS, Rast G, Rosenbrock H. Differential effect of the mGlu5 receptor positive allosteric modulator ADX-47273 on early and late hippocampal LTP. Neuropharmacology. 2011 Sep;61(4):707-14. PMID: 21640734.

Schlumberger C, Pietraszek M, Gravius A, et al. Comparison of the mGlu(5) receptor positive allosteric modulator ADX47273 and the mGlu(2/3) receptor agonist LY354740 in tests for antipsychotic-like activity. Eur J Pharmacol. 2009 Nov 25;623(1-3):73-83. PMID: 19765575.

Liu F, Grauer S, Kelley C, et al. ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities. J Pharmacol Exp Ther. 2008 Dec;327(3):827-39. PMID: 18753411.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A985136

    AZD5991

    Mcl-1 inhibitor

    ≥99%
  • L0108

    Lacidipine

    Calcium channel blocker.

    ≥98%
  • T3031

    Thienylbutyl Isothiocyanate

    ITC.

    ≥96%
  • N1986

    Neuropeptide Y, human/rat

    Endogenous peptide neurotransmitter, involved i...

    ≥95%
  • D0255

    Dantrolene Sodium Heptahydrate

    Hydantoin derivative; RyR antagonist, L-type Ca...

    ≥98%
  • M0368

    Marbofloxacin

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • C3214

    CID-797718

    Potential PKD binding agent.

    ≥99%
  • A5193

    Amygdalin

    Glucoside found in stone fruits and apples.

    ≥98%
  • O783720

    OTS-964

    Inhibitor of T-lymphokine-activated killer cell...

    ≥98%
  • P6859

    Proctolin

    Neuropeptide found in crustaceans and insects.<...

    ≥95%
  • R3221

    3-Formylrifamycin

    Rifamycin derivative, induces pore formation in...

    ≥98%
  • B807214

    Buflomedil Hydrochloride

    Alpha blocker and vasoactive agent.

    ≥99%
  • D5607

    Dobutamine Hydrochloride

    β1-adrenergic agonist, β2- and α1-adrenergic...

    ≥98%
  • B8276

    Butyric Acid Sodium

    HDAC inhibitor, RNA splicing modulator.

    ≥98%
  • G7344

    GSK-2334470

    PI3K and PDK1 inhibitor.

    ≥99%, ≥99%ee
  • H9614

    Hydrochlorothiazide

    Thiazide diuretic; NCCT inhibitor, carbonic anh...

    ≥98%
  • M1579

    Methazolamide

    Carbonic anhydrase inhibitor.

    ≥98%
  • O9234

    Oxiconazole Nitrate

    Imidazole; 14-α demethylase inhibitor.

    ≥98%
  • H9714

    L-5-Hydroxytryptophan

    Endogenous amino acid, precursor of 5-HT and me...

    ≥98%
  • D490280

    DMH-1

    Inhibitor of BMP.

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only