[Ala19]-Glucagon-like Peptide II, rat

Product ID G4485

Cas No. 89750-15-2

Purity ≥95%

Unit Size	Cost	Quantity		Stock

Bulk Quote

Add to Wishlist

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description
Product Info
Shipping and Storage
Downloads
References
Custom Order

Description

Glucagon-like peptide 2 (GLP-2) is a peptide hormone primarily synthesized in the intestine and pancreas. GLP-2 binds and activates the GLP-2 receptor, exhibiting vasodilatory, antihypertensive, antidepressant, and gastrointestinal motility modulating activities. In animal models, GLP-2 increases intestinal blood flow and decreases mean arterial blood pressure. GLP-2 potentiates L-type voltage-gated Ca2+ channels through a mechanism that involves activation of PKA. Additionally, GLP-2 decreases immobility time in animals undergoing the forced swim test. This peptide stimulates cell proliferation, inhibiting chemotherapy-induced mucosal atrophy in the intestines. GLP-2 also decreases gastric emptying and gastrointestinal motility.

Product Info

Cas No.	89750-15-2
Purity	≥95%
Formula	C₁₆₅H₂₅₄N₄₄O₅₅S
Formula Wt.	3766.2
Synonym	GLP-2

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	G4485 MSDS PDF
Info Sheet	G4485 Info Sheet PDF

References

Sasaki-Hamada S, Ito K, Oka JI. Neuronal Fos-like immunoreactivity associated with dexamethasone-induced hypertension in rats and effects of glucagon-like peptide-2. Life Sci. 2013 Oct 24. pii: S0024-3205(13)00618-8. [Epub ahead of print]. PMID: 24513200.

Hansen LB. GLP-2 and mesenteric blood flow. Dan Med J. 2013 May;60(5):B4634. PMID: 23673268.

Rasmussen AR, Viby NE, Hare KJ, et al. The intestinotrophic peptide, GLP-2, counteracts the gastrointestinal atrophy in mice induced by the epidermal growth factor receptor inhibitor, erlotinib, and cisplatin. Dig Dis Sci. 2010 Oct;55(10):2785-96. PMID: 20112065.

Wang Y, Guan X. GLP-2 potentiates L-type Ca2+ channel activity associated with stimulated glucose uptake in hippocampal neurons. Am J Physiol Endocrinol Metab. 2010 Feb;298(2):E156-66. PMID: 19920220.

Iwai T, Hayashi Y, Narita S, et al. Antidepressant-like effects of glucagon-like peptide-2 in mice occur via monoamine pathways. Behav Brain Res. 2009 Dec 1;204(1):235-40. PMID: 19539656.

Mojsov S, Kopczynski MG, Habener JF. Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas. J Biol Chem. 1990 May 15;265(14):8001-8. PMID: 1692320.