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Alendronate Monosodium Trihydrate

Alendronate Monosodium Trihydrate

Product ID A4515
Cas No. 121268-17-5
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $128.30 In stock
500 mg $448.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
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  • Custom Order

Description

Alendronate is a second generation bisphosphonate that exhibits anti-resorptive, anti-inflammatory, immunomodulatory, and anticancer chemotherapeutic activities. Alendronate inhibits bone resorption but does not have any effects on bone mineralization; it also inhibits osteoclast formation and decreases phosphorylation of Akt and ERK1/2 in vitro. In animal models, alendronate decreases production of Th2 and Th17 cytokines and eotaxin-2, suppressing antigen-induced pulmonary immune responses. Additionally, this compound increases δγ T cell activation and inhibits tumor growth in vivo.

Product Info

Cas No.

121268-17-5

Purity

≥98%

Formula

C4H12NNaO7P2 • 3H2O

Formula Wt.

325.08

Chemical Name

4-Amino-1-hydroxybutylidine-1,1-bisphosphate

IUPAC Name

sodium;(4-amino-1-hydroxy-1-phosphonobutyl)-hydroxyphosphinate

Synonym

Alendronic acid, ABDP

Melting Point

233-235°C (dec)

Solubility

Soluble in water (10 mg/mL). PBS 0.25 mg/mL. DMSO <1 mg/mL.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A4515 MSDS PDF

Info Sheet

A4515 Info Sheet PDF

References

Tsubaki M, Komai M, Itoh T, et al. Nitrogen-containing bisphosphonates inhibit RANKL- and M-CSF-induced osteoclast formation through the inhibition of ERK1/2 and Akt activation. J Biomed Sci. 2014 Feb 3;21:10. PMID: 24490900.

Sasaki O, Imamura M, Yamazumi Y, et al. Alendronate attenuates eosinophilic airway inflammation associated with suppression of Th2 cytokines, Th17 cytokines, and eotaxin-2. J Immunol. 2013 Sep 15;191(6):2879-89. PMID: 23935198.

Gutman D, Epstein-Barash H, Tsuriel M, et al. Alendronate liposomes for antitumor therapy: activation of γδ T cells and inhibition of tumor growth. Adv Exp Med Biol. 2012;733:165-79. PMID: 22101722.

Takahashi H, Kinbara M, Sato N, et al. Nickel allergy-promoting effects of microbial or inflammatory substances at the sensitization step in mice. Int Immunopharmacol. 2011 Oct;11(10):1534-1540. PMID: 21621645.

Custom Order

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