LKT Labs

Biochemicals for Life Science Research

Alsterpaullone

Alsterpaullone

Product ID A4577
Cas No. 237430-03-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $162.00 In stock
5 mg $623.00 In stock
Bulk Quote

Quicklinks

Description

Alsterpaullone exhibits anticancer, anti-angiogenic, antiviral, and neuroprotective activities. Alsterpaullone inhibits cyclin-dependent kinases (CDKs), inducing G2/M phase cell cycle arrest and apoptosis in leukemia cells. Additionally, alsterpaullone inhibits glycogen synthase kinase 3 (GSK-3), inducing Wnt signaling; in ticks, this results in anti-fertility potential, decreasing egg hatching activity. Alsterpaullone also inhibits HIV-1 replication and proliferation. In ex vivo models of Alzheimer’s disease, this compound protects against neuronal death and decreases phosphorylation of tau protein.

Product Info

Cas No.

237430-03-4
Purity

≥98%
Formula

C16H11N3O3
Formula Wt.

293.28
IUPAC Name

9-nitro-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one
Synonym

9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one
Solubility

Soluble in DMSO.
Appearance

Yellow to Brown Powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

A4577 MSDS PDF
Info Sheet

A4577 Info Sheet PDF

References

Cui C, Wang Y, Wang Y, et al. Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect. J Anal Methods Chem. 2013;2013:602091. PMID: 23577282.

Windsor PJ, Leys SP. Wnt signaling and induction in the sponge aquiferous system: evidence for an ancient origin of the organizer. Evol Dev. 2010 Sep-Oct;12(5):484-93. PMID: 20883217.

Zahler S, Liebl J, Fürst R, et al. Anti-angiogenic potential of small molecular inhibitors of cyclin dependent kinases in vitro. Angiogenesis. 2010 Sep;13(3):239-49. PMID: 20706783.

Fabres A, De Andrade CP, Guizzo M, et al. Effect of GSK-3 activity, enzymatic inhibition and gene silencing by RNAi on tick oviposition and egg hatching. Parasitology. 2010 Sep;137(10):1537-46. PMID: 20500916.

Guendel I, Agbottah ET, Kehn-Hall K, et al. Inhibition of human immunodeficiency virus type-1 by cdk inhibitors. AIDS Res Ther. 2010 Mar 24;7(1):7. PMID: 20334651.

Selenica ML, Jensen HS, Larsen AK, et al. Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation. Br J Pharmacol. 2007 Nov;152(6):959-79. PMID: 17906685.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T1008

    10,13-Bissidechain Paclitaxel

    Synthesis impurity

    ≥90%
  • H9618

    Hydroquinone

    Basic phenol skeleton structure found in variou...

    ≥96%
  • D3352

    Dinaciclib

    BRD binding agent, CDK1/2/5/9 inhibitor.

    ≥99%
  • A0920

    N-Acetyl-S-(N′-phenethylthiocarbamoyl)-L-cysteine

    N-acetyl cysteine conjugate of phenethylisothio...

    ≥95%
  • F4532

    Flibanserin

    5-HT1A agonist, 5-HT2A antagonist.

    ≥97%
  • R3477

    Ritodrine Hydrochloride

    Phenylethylamine; β2-adrenergic agonist, SK/BK...

    ≥98%
  • A6818

    Arenobufagin

    Bufanolide steroid found in Bufo arenarum;VEGFR...

    ≥98%
  • P9869

    Pyridoxine Hydrochloride

    Vitamin B6 derivative, antioxidant.

    ≥98%
  • M1646

    Melanin Concentrating Hormone, human/mouse/rat

    Endogenous peptide hormon involved in energy ho...

    ≥98%
  • P6857

    Protocatechuic Acid

    Polyphenol found in many plants and foods.

    ≥97%
  • O446185

    Oleuropein

    Bioactive compound from olive tree.

    ≥98%
  • Z1602

    Zearalenone

    Mycotoxin produced by Fusarium; ER agonist.

    ≥98%
  • C5972

    Corynoline

    Alkaloid compound originally found in Corydalis...

    ≥98%
  • S8045

    S-Sulforaphane

    Synthetic antioxidant that induces phase II enz...

    ≥96%
  • I525138

    Indoximod

    Indoleamine 2,3-dioxygenase inhibitor.

    ≥98%
  • P1200

    PD-184352

    MEK1/2 and Raf inhibitor.

    ≥98%
  • R8206

    Rubescensin A

    Diterpene originally found in Rabdosia.

    ≥93%
  • N7332

    NSI-189

    Stem cell neurogenesis inducer.

    ≥99%
  • F8250

    Fumitremorgin C

    Mycotoxin found in Aspergillus and Penicillum; ...

    ≥98%
  • S1605

    Secretin, human

    Endogenous peptide hormone, involved in water h...

    ≥95%