Amlodipine

Name: Amlodipine
SKU: A5045
Availability: InStock

Product ID A5045

Cas No. 88150-42-9

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Amlodipine is a dihydropyridine L-type Ca2+ channel blocker that exhibits antihypertensive, anti-anginal, and vasodilatory activities. Amlodipine is clinically used to treat hypertension and angina as it induces relaxation of arterial smooth muscles, decreases blood pressure, and increases blood flow to the heart. Amlodipine also inhibits acid sphingomyelinase (FIASMA), which is involved in programmed cell death. Additionally, this compound improves smooth muscle hypertrophy and collagen deposition, preventing arterial remodeling in hypertensive rats.

Product Info

Cas No.	88150-42-9
Purity	≥98%
Formula	C₂₀H₂₅ClN₂O₅
Formula Wt.	408.88
Chemical Name	2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4- dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester
IUPAC Name	3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1, 4-dihydropyridine-3,5-dicarboxylate
Synonym	UK-48340
Melting Point	134-136°C
Solubility	Soluble in methanol, ethanol (82mg/mL)choroform and DMSO (82mg/mL).
Appearance	Almost White Crystal Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	A5045 MSDS PDF
Info Sheet	A5045 Info Sheet PDF

References

Chen JL, Shang QH, Hu W, et al. Role of TGF-β1/Smads pathway in carotid artery remodeling in renovascular hypertensive rats and prevention by Enalapril and Amlodipine. J Geriatr Cardiol. 2012 Jun;9(2):185-91. PMID: 22916067.

Kornhuber J, Tripal P, Reichel M, et al. Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications. Cell Physiol Biochem. 2010;26(1):9-20. PMID: 20502000.

Wang JG. A combined role of calcium channel blockers and angiotensin receptor blockers in stroke prevention. Vasc Health Risk Manag. 2009;5:593-605. PMID: 19688100.

Fan YY, Kohno M, Nakano D, et al. Cilnidipine suppresses podocyte injury and proteinuria in metabolic syndrome rats: possible involvement of N-type calcium channel in podocyte. J Hypertens. 2010 May;28(5):1034-1043. PMID: 20411599.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Comments
This field is for validation purposes and should be left unchanged.

Amlodipine

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

4-Aminosalicylic Acid

Guaifenesin

Itaconic Acid

Madecassic Acid

Pimecrolimus

Chlorpheniramine Maleate

Milrinone

S-(N-Methylthiocarbamoyl)-L-cysteine

Propantheline Bromide

Angiotensinogen (1-14), human

Cycloastragenol

β-Zearalenol

Alternariol

(±)-Warfarin

Sertraline Hydrochloride

4-Aminophenylphosphate Monosodium

Ro 20-1724

[Val5]-Angiotensin II, human

Vardenafil Dihydrochloride

4’-Bromoflavone

Footer