Description
Ansamitocin P3 induces microtubule depolymerization by binding tubulin; it exhibits immunomodulatory and anticancer activities. Ansamitocin P3 increases T cell signaling and antigen uptake and decreases regulatory T cell levels in vivo.
Product Unit Size | Cost | Quantity | Stock |
---|
Ansamitocin P3 induces microtubule depolymerization by binding tubulin; it exhibits immunomodulatory and anticancer activities. Ansamitocin P3 increases T cell signaling and antigen uptake and decreases regulatory T cell levels in vivo.
Cas No. | 66547-09-9 |
---|---|
Purity | ≥70% (P3), Total Ansamitocins ≥95% |
Formula | C32H43CIN2O9 |
Formula Wt. | 635.14 |
IUPAC Name | [(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] butanoate |
Synonym | Maytansinol butyrate |
Solubility | 10mM DMSO |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Martin K, Müller P, Schreiner J, et al. The microtubule-depolymerizing agent ansamitocin P3 programs dendritic cells toward enhanced anti-tumor immunity. Cancer Immunol Immunother. 2014 Sep;63(9):925-38. PMID: 24906866.
Venghateri JB, Gupta TK, Verma PJ, et al. Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at the vinblastine site. PLoS One. 2013 Oct 4;8(10):e75182. PMID: 24124473.
Effective against gram-positive pathogens
Selective positive allosteric modulator of AMPA...
Fluoroquinolone; topoisomerase IV and bacterial...
Pentacyclic triterpene found in various plant s...
Fluoroquinolone; topoisomerase IV and bacterial...
DNA alkylator.
Fluorogenic substrate used to measure serine pr...
Peptide fragment of HIV-1 gp120.
Potential PKD binding agent.
Synthetic derivative of 6-methylsulfinyl-hexane...
5-HT1A agonist, 5-HT1B partial agonist, 5-HT3A/...
BHA derivative.
Synthetic glycolipid found in Agelas mauritaniu...
Coccidiostat; dihydrofolate reductase inhibitor...
FIASMA, 5-HT3 and σ1 agonist, SERT inhibitor.<...
Mycotoxin, metabolite of aflatoxin B1 produced ...
Mycotoxin produced by Alternaria; photosynthesi...
Peptide, cleavage product of proenkephalin; κO...
Sulfonamide; PABA inhibitor.
Steroid found in myrrh; FXR antagonist.