Name: Ansamitocin P3
SKU: A5472
Availability: InStock

Description

Ansamitocin P3 induces microtubule depolymerization by binding tubulin; it exhibits immunomodulatory and anticancer activities. Ansamitocin P3 increases T cell signaling and antigen uptake and decreases regulatory T cell levels in vivo.

Product Info

Cas No.	66547-09-9
Purity	≥70%
Formula	C₃₂H₄₃CIN₂O₉
Formula Wt.	635.14
Solubility	10mM DMSO

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	A5472 MSDS PDF
Info Sheet	A5472 Info Sheet PDF

References

Martin K, Müller P, Schreiner J, et al. The microtubule-depolymerizing agent ansamitocin P3 programs dendritic cells toward enhanced anti-tumor immunity. Cancer Immunol Immunother. 2014 Sep;63(9):925-38. PMID: 24906866.

Venghateri JB, Gupta TK, Verma PJ, et al. Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at the vinblastine site. PLoS One. 2013 Oct 4;8(10):e75182. PMID: 24124473.

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Ansamitocin P3

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