| Product Unit Size | Cost | Quantity | Stock |
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Antimycin A was initially produced by Streptomyces. Antimycin A binds cytochrome c reductase, inhibiting electron transport chain activity, oxidative phosphorylation, and ATP synthesis. Antimycin A is used in research models to study mitochondrial respiration and superoxide production.
| Cas No. | 1397-94-0 |
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| Formula | C28H40N2O9 |
| Formula Wt. | 548.63 |
| Chemical Name | 3-Methylbutanoic acid 3-[[3-(formylamino)-2- hydroxy benzoyl]amino]-8-hexyl-2,6-dimethyl-4,9- dioxo-1,5-dioxonan-7-yl ester |
| IUPAC Name | [(2R,3S,6S,7R,8R)-3-[(3-formamido-2-hydroxybenzoyl)amino]-8-hexyl-2, 6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate |
| Synonym | Isovaleric acid 8-ester with 3-formamido-N-(7-hexyl- 8-hydroxy-4,9-dimethyl-2,6-dioxo-1,5-dioxonan-3,yl)- salicylamide |
| Melting Point | 149-150°C |
| Solubility | Soluble in alcohol, ethanol (50mg/mL),ether, acetone, or chloroform. Slightly soluble in benzene or carbon tetrachloride. Insoluble in water. |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Taddeo EP, Laker RC, Breen DS, et al. Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle. Mol Metab. 2013 Nov 26;3(2):124-34. PMID: 24634818.
Ma X, Jin M, Cai Y, et al. Mitochondrial electron transport chain complex III is required for antimycin A to inhibit autophagy. Chem Biol. 2011 Nov 23;18(11):1474-81. PMID: 22118681.
Quinlan CL, Gerencser AA, Treberg JR, et al. The mechanism of superoxide production by the antimycin-inhibited mitochondrial Q-cycle. J Biol Chem. 2011 Sep 9;286(36):31361-72. PMID: 21708945.