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Artemisinin

Artemisinin

Product ID A6978
Cas No. 63968-64-9
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $60.10 In stock
500 mg $142.80 In stock
1 g $248.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Artemisinin is a sesquiterpene lactone originally found in Artemisia (wormwood); it is clinically used to treat malaria. Artemisinin exhibits anti-parasitic, antimalarial, cardioprotective, anticancer, and anti-inflammatory activities. This compound inhibits growth of Plasmodium. In animal models of myocardial infarction, artemisinin decreases ventricular fibrillation threshold and levels of TNF-α and increases expression of connexin 43. In macrophages, this compound inhibits IL-6 release. Artemisinin also inhibits growth of neuroblastoma cells, increasing activation of AMPK and decreasing signaling by mTOR.

Product Info

Cas No.

63968-64-9

Purity

≥98%

Formula

C15H22O5

Formula Wt.

282.35

Chemical Name

(3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-tri- methyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzo- dioxepin-10(3H)-one

IUPAC Name

(1R,4S,5R,8S,9R,12S,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one

Synonym

Artemisine, Arteannuin, Quinghaosu, QHS

Melting Point

156-157°C

Solubility

Insoluble in water. Soluble in methanol (24mg/ml), acetone, ethanol, DMF, DMSO (57 mg/ml) at 25° C, acetone, chloroform (25 mg/ml), DCM, and ethyl acetate;

Appearance

White crystalline solid

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A6978 MSDS PDF

Info Sheet

A6978 Info Sheet PDF

References

Gu Y, Wu G, Wang X, et al. Artemisinin prevents electric remodeling following myocardial infarction possibly by upregulating the expression of connexin 43. Mol Med Rep. 2014 Oct;10(4):1851-6. PMID: 25110145.

Tan WQ, Chen G, Jia B, et al. Artemisinin inhibits neuroblastoma proliferation through activation of AHP-activated protein kinase (AMPK) signaling. Pharmazie. 2014 Jun;69(6):468-72. PMID: 24974584.

Patel K, Batty KT, Moore BR, et al. Predicting the parasite killing effect of artemisinin combination therapy in a murine malaria model. J Antimicrob Chemother. 2014 Aug;69(8):2155-63. PMID: 24777899.

Yu WY, Kan WJ, Yu PX, et al. Anti-inflammatory effect and mechanism of artemisinin and dihydroartemisinin. Zhongguo Zhong Yao Za Zhi. 2012 Sep;37(17):2618-21. PMID: 23236763.

Custom Order

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