• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Asciminib Hydrochloride

Asciminib Hydrochloride

Product ID A724092
Cas No. 2119669-71-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $99.20 In stock
5 mg $275.60 In stock
25 mg $793.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Asciminib is an orally bioavailable, allosteric Bcr-Abl1 tyrosine kinase inhibitor, with antineoplastic activity. Upon administration, asciminib targets and binds to the myristoyl pocket of the Bcr-Abl1 fusion protein at a location that is distinct from the ATP-binding domain, thereby inhibiting the activity of both wild-type Bcr-Abl and certain mutation forms, including the T315I mutation. This binding results in the inhibition of Bcr-Abl1-mediated proliferation and enhanced apoptosis of Philadelphia chromosome-positive (Ph+) hematological malignancies. The Bcr-Abl1 fusion protein tyrosine kinase is an abnormal enzyme produced by leukemia cells that contain the Philadelphia chromosome.
NCI Thesaurus (NCIt)

Product Info

Cas No.

2119669-71-3

Purity

≥98%

Formula

C20H19Cl2F2N5O3

Formula Wt.

486.30

Chemical Name

N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;hydrochloride

IUPAC Name

N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;hydrochloride

Synonym

ABL001 Hydrochloride; ABL001 HCl; Scemblix; ABL001-AAA; C5U34S9XFV

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

A724092 Info Sheet PDF

References

Gleixner K, Filik Y, Berger D, et al. Asciminib and ponatinib exert synergistic anti-neoplastic effects on CML cells expressing BCR-ABL1T315I-compound mutations. Am J Cancer Res. 2021 Sep 15;11(9):4470-4484. PMID: 34659899

Rea D, Hughes T. Development of asciminib, a novel allosteric inhibitor of BCR-ABL1. Crit Rev Oncol Hematol. 2022 Mar;171:103580. PMID: 35021069

Oruganti B, Lindahl E, Yang J, et al. Allosteric enhancement of the BCR-Abl1 kinase inhibition activity of nilotinib by cobinding of asciminib. J Biol Chem. 2022 Aug;298(8):102238. PMID: 35809644

Lin H, Saputra F, Audira G, et al. Investigating potential cardiovascular toxicity of two anti-leukemia drugs of asciminib and ponatinib in zebrafish embryos. Int J Mol Sci. 2022 Oct 3;23(19):11711. PMID: 36233014

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • O7992

    OTX-015

    BRD2/3/4 inhibitor.

    ≥98%
  • C0251

    Calcitonin Gene Related Peptide II, rat

    Calcitonin-family peptide, involved in vasodila...

    ≥95%
  • C0266

    Capsaicin, natural

    Found in Capsicum; TRPV agonist.

    ≥95%, capsaicinoids content
  • M185777

    4-(Methylsulfinyl) butylamine

    ≥99%
  • C458567

    Clofazimine

    Antibacterial (Antimyobacterial) agent.

    ≥99%
  • E9317

    Exemestane

    Aromatase inhibitor.

    ≥97%
  • A5135

    Aminophylline Dihydrate

    Xanthine derivative; adenosine antagonist, PDE ...

    ≥98%
  • B0109

    Bakuchiol

    Prenylated phenolic terpene found in various pl...

    ≥98%
  • E5456

    Enocitabine

    Cytarabine derivative, nucleoside (cytosine) an...

    ≥95%
  • A9713

    AZD-3514

    Androgen receptor downregulator.

    ≥98%
  • R2815

    Recombinant HIV-1 “0” group consensus

    Recombinant HIV-1 antigen fragment.

    ≥95%
  • D1773

    Deshydroxy LY-411575

    γ-Secretase inhibitor.

    ≥98%
  • C2800

    Chalcone

    Enone.

    ≥97%
  • C0265

    Carnosic Acid

    Diterpene found in Rosmarinus.

    ≥98%
  • H0002

    H8 dihydrochloride

    PKA inhibitor.

    ≥98%
  • B5560

    B-type Natriuretic Peptide (1-32), rat

    Endogenous cardiomodulatory peptide; NPR-A agon...

    ≥95%
  • A4646

    ALLN

    Calpain I/II inhibitor.

    ≥98%
  • I7757

    Itopride Hydrochloride

    AChE inhibitor, D2 antagonist.

    ≥98%
  • F5874

    Fosfomycin Calcium

    MurA and isopentenyl mevalonate kinase inhibito...

    ≥95%
  • L5873

    Losartan Potassium

    AT1 antagonist.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only