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Asunaprevir

Product ID A745817
Cas No. 630420-16-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $111.80 In stock
5 mg $323.70 In stock
25 mg $1,030.10 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Asunaprevir is an antiviral bioactive small molecule. It has been found to inhibit cytopathic effects in Vero E6 cells, decrease virion release from infected cells, and inhibit propagation in lung Clu-3 cells, after infection with SARS-CoV-2. Asunaprevir is a second-generation NS3 protease inhibitor affective against HCV genotypes 1 and 4.

Product Info

Cas No.

630420-16-5

Purity

≥98%

Formula

C35H46ClN5O9S

Formula Wt.

747.29

Chemical Name

tert-butyl N-[(2S)-1-[(2S,4R)-4-(7-chloro-4-methoxyisoquinolin-1-yl)oxy-2-[[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate

IUPAC Name

tert-butyl N-[(2S)-1-[(2S,4R)-4-(7-chloro-4-methoxyisoquinolin-1-yl)oxy-2-[[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate

Synonym

BMS-650032

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A745817 MSDS PDF

Info Sheet

A745817 Info Sheet PDF

References

Lim Y, Ngyuen L, Lee G, et al. Asunaprevir, a potent hepatitis C virus protease inhibitor, blocks SARS-CoV-2 propagation. Mol Cells. 2021 Sep 30;44(9):688-695. PMID: 34518443.

Akamatsu N, Sugawara Y, Kokudo N. Asuaprevir (BMS-650032) for the treatment of hepatitis C virus. Expert Rev Anti Infect Ther. 2015;13(11):1307-1317. PMID: 26414905.

Gentile I, Zappulo E, Buonomo A, et al. Asunaprevir for hepatitis C: a safety evaluation. Expert Opin Drug Saf. 2015 Oct;14(10):1631-1646. PMID: 26329454.

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