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Aureothricin is a member of the dithiolopyrrolone family of antibiotics that are synthesized by Streptomyces species. Aureothricin is a chemical analog of thiolutin, another member of this family. The dithiolopyrrolone family members contain a heterobicyclic core with a disulfide bridge between two ene-thiols. The dithiolopyrrolone core gives these antibiotics a characteristic electronically unique stucture.
| Cas No. | 574-95-8 |
|---|---|
| Purity | ≥98% |
| Formula | C9H10N2O2S2 |
| Formula Wt. | 242.31 |
| Chemical Name | N-(4-methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)propanamide |
| IUPAC Name | ~{N}-(4-methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)propanamide |
| Synonym | Farcinicin, Propionylpyrrothione; UNII-0KX00L19Q2; 0KX00L19Q2 |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Huang S, Yu Y. [Biosynthesis and metabolic engineering of dithiolopyrrolone- A review]. Wei Sheng Wu Xue Bao. 2016 Mar 4;56(3):383-396. PMID: 27382782.
Zhai Y, Bai S, Liu J, et al. Identification of an unusual type II thioesterase in the dithiolopyrrolone antibiotics biosynthetic pathway. Biochem Biophys Res Commun. 2016 Apr 22;473(1):329-335. PMID: 27018252.
Li B, Wever WJ, Walsh CT, et al. Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics. Nat Prod Rep. 2014 Jul;31(7):905-923. PMID: 24835149.