LKT Labs

Biochemicals for Life Science Research

AZD-1152-HQPA

AZD-1152-HQPA

Product ID A9714
Cas No. 722544-51-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $118.00 In stock
5 mg $219.00 In stock
10 mg $355.00 In stock
Bulk Quote

Quicklinks

Description

AZD-1152-HQPA inhibits aurora kinases B and C (AurB, AurC), preventing mitotic spindle formation and proper completion of mitosis. This compound exhibits anticancer chemotherapeutic activity and is currently in clinical trials as a potential treatment for cancers with solid tumors. In acute myelogenous leukemia (AML) and acute lymphocytic leukemia (ALL) cells, AZD-1152-HQPA induces apoptosis, inhibiting proliferation. AZD-1152-HQPA also induces apoptosis in glioma cells, inhibiting proliferation in vitro and tumor growth in vivo.

Product Info

Cas No.

722544-51-6
Purity

≥98%
Formula

C26H30FN7O3
Formula Wt.

507.56
IUPAC Name

2-[3-[[7-[3-[ethyl(2-hydroxyethyl)amino]propoxy]quinazolin-4-yl]amino]-1H-pyrazol-5-yl]-N-(3-fluorophenyl)acetamide
Synonym

AZD1152-HQPA
Solubility

DMSO 102 mg/mL (200.96 mM) Ethanol 3 mg/mL (5.91 mM) Water Insoluble
Appearance

Off-white Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

A9714 MSDS PDF
Info Sheet

A9714 Info Sheet PDF

References

Hartsink-Segers SA, Zwaan CM, Exalto C, et al. Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target. Leukemia. 2013 Mar;27(3):560-8. PMID: 22940834.

Diaz RJ, Golbourn B, Shekarforoush M, et al. Aurora kinase B/C inhibition impairs malignant glioma growth in vivo. J Neurooncol. 2012 Jul;108(3):349-60. PMID: 22382783.

Boss DS, Witteveen PO, van der Sar J,et al. Clinical evaluation of AZD1152, an i.v. inhibitor of Aurora B kinase, in patients with solid malignant tumors. Ann Oncol. 2011 Feb;22(2):431-7. PMID: 20924078.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B6935

    Brivudine

    Nucleoside (thymidine) analog; DNA chain termin...

    ≥98%
  • C9878

    Cytochalasin A

    Mycotoxin produced by Aspergillus; actin polyme...

    ≥98%
  • M0803

    MC1568

    HDAC inhibitor. May reduce blood pressure in hy...

    ≥98%
  • A822686

    Aureothricin

    Aureothricin is a member of the dithiolopyrrolo...

    ≥98%
  • T1855

    Tentoxin

    Cyclic peptide mycotoxin produced by Alternaria...

    ≥98%, HPLC
  • S8251

    Sulfluramid

    Perfluorinated insecticide.

    ≥95%
  • C2997

    Chymostatin

    Protease inhibitor.

    ≥95% (mixture of A, B, C)
  • T0091

    7-(Triethylsilyl)-10-deacetylbaccatin III

    Taxol derivative.

    ≥97%
  • P7058

    Protocatechuic Aldehyde

    Polyphenol found in various plants and foods.

    ≥98%
  • A0822

    N-Acetyl-S-(N-methylsulfinylbutylthiocarbamoyl)-L-cysteine

    Sulforaphane-cysteine conjugate.

    ≥98%
  • H9611

    Hydrocortisone

    Endogenous steroid hormone involved in stress s...

    ≥98%
  • C0148

    Calcitonin, human

    Endogenous neuropeptide hormone, lowers extrace...

    ≥95%
  • R2812

    Recombinant HIV-1 gp-120

    Recombinant HIV glycoprotein antigen fragment.<...

    ≥95%
  • T6834

    Triacsin C

    Acyl-CoA synthetase inhibitor.

    ≥95%
  • V1769

    Verapamil Hydrochloride

    L-type Ca2+ channel blocker.

    ≥98%
  • X1753

    Xenopsin

    Peptide hormone, neurotensin analog found in am...

    ≥95%
  • S0132

    Saikosaponin A

    Triterpene saponin found in Bupleurum.

    ≥98%
  • C2945

    Chlorophyllin Sodium-Copper Salt

    Semi-synthetic derivative of chlorophyll; food ...

    USP 28
  • P3563

    Piperlonguminine

    Found in Piper longum.

    ≥99%
  • R2712

    Recombinant HCV-NS3 Antigens

    Recombinant HCV antigen fragment.

    ≥95%